Growth Factors

by Georgina Cornwall, PhD

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    00:00 So growth factors that we've learned about previously often help move through the cell cycle by interaction with receptor tyrosine kinases and we've explored those in the second messenger systems lecture.

    00:20 So how does this come into play? Let's give an example.

    00:25 Let's say that you're out in the field running around and you cut your arm on a barbed wire fence.

    00:33 So now you have a big gash in your arm. So we've got some damaged tissue.

    00:37 And your inflammatory response system is going to come into play and a blood clot will form. Part of that blood clot are platelets.

    00:47 Now platelets produce a growth factor called platelet-derived growth factor and that growth factor is going to promote division of cells so that we can repair the tissues.

    01:01 So platelet-derived growth factors can override these cell cycle controls in order to make things move faster and accelerate cell division.

    01:13 So this is a good thing. Again, signals using receptor tyrosine kinases can override the systems that are in play to put the breaks on or the gas pedal.

    01:25 These cell cycle controls, I think of them as a break pedal, "We're not ready to go", or a gas pedal, "Let's move on", right.

    01:34 So again, a quick review of how these signal transduction cascades work.

    01:42 We have our receptor tyrosine kinases in the membrane over here. And when there are growth factor binds, those two dimerized and we then will see that the switch, the Ras switch would be turned on.

    01:58 And that would allow the map kinase cascade, in this case, a little bit different of a cascade, but the same kind of idea.

    02:05 And then we end up with mitosis-activating protein kinases, in this specific case, it's ERK.

    02:14 It's not really important what that is, but now we're allowed to move into the nucleus and have transcription and translation of the necessary machinery for whatever phase of the cell cycle it is.

    02:26 So again this is just an example of one of the means of cell communication that comes into play, putting that into perspective with something real, otherwise why on earth would you need to know all of these different cascades.

    02:41 So there is some importance to that.

    About the Lecture

    The lecture Growth Factors by Georgina Cornwall, PhD is from the course Cell Cycle and Cell Division.

    Included Quiz Questions

    1. RTK dimerizes
    2. RTK activates RAS.
    3. MAP kinase activates transcription factors.
    4. RAS activates the protein kinase, RAF.
    5. MEK activates MAP kinase(ERK).

    Author of lecture Growth Factors

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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    Reading Notes
    By Shaheen S. on 08. December 2018 for Growth Factors

    I feel like she is just reading notes that she has been just handed over.

    Review of cell biology.
    By Tawfic G. on 20. September 2018 for Growth Factors

    Feels like she is not comfortable with information she is teaching. Accuracy of information (and spelling!) is sometimes questionable.

    best explaination
    By spot l. on 03. June 2018 for Growth Factors

    best prof in the world explains everything so good that even a kid will understand