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Glycolysis: 1,3 BPG –> 3-PG – Glycolysis and Pyruvate Metabolism

by Kevin Ahern, PhD
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    00:00 The next reaction of the pathway is where we start to create ATPs.

    00:06 In this reaction 1,3-bisphosphoglycerate is converted into a molecule called 3-phosphoglycerate, and this is a pretty straight forward reaction.

    00:15 You see the phosphate on position 1 on the left being removed and transferred to ADP to make ATP by the enzyme phosphoglycerate kinase.

    00:25 Now this reaction is interesting in the sense as what we call a substrate level phosphorylation.

    00:33 A substrate level phosphorylation occurs when a high energy molecule transfers a phosphate onto ADP to make ATP which is exactly what you have seen here.

    00:44 Now many people think mistakenly that this is the way most ATPs is made in the cell, by simply having a high energy molecule to transfer.

    00:54 It doesn't occur that way. And in fact most of the ATP in cells is made by a process called oxidative phosphorylation.

    01:01 This is an unusual reaction in a sense that ATP is made directly.

    01:07 We will see another one of those later in glycolysis.

    01:09 The delta G zero prime for this reaction is very energetically favorable, meaning -18.9 kJ/mol. It moves very strongly to the right and since we are making an ATP what that tells us is that there is a lot energy in 1,3-bisphophoglycerate in order to make this happen so efficiently.


    About the Lecture

    The lecture Glycolysis: 1,3 BPG –> 3-PG – Glycolysis and Pyruvate Metabolism by Kevin Ahern, PhD is from the course Carbohydrate Metabolism.


    Included Quiz Questions

    1. It results in a substrate level phosphorylation
    2. It is catalyzed by phosphoglycerate mutase
    3. It is the only oxidation in glycolysis
    4. It is not very energetically favorable

    Author of lecture Glycolysis: 1,3 BPG –> 3-PG – Glycolysis and Pyruvate Metabolism

     Kevin Ahern, PhD

    Kevin Ahern, PhD


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