Glycolysis: 1,3 BPG –> 3-PG – Glycolysis and Pyruvate Metabolism

by Kevin Ahern, PhD

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    00:00 The next reaction of the pathway is where we start to create ATPs.

    00:06 In this reaction 1,3-bisphosphoglycerate is converted into a molecule called 3-phosphoglycerate, and this is a pretty straight forward reaction.

    00:15 You see the phosphate on position 1 on the left being removed and transferred to ADP to make ATP by the enzyme phosphoglycerate kinase.

    00:25 Now this reaction is interesting in the sense as what we call a substrate level phosphorylation.

    00:33 A substrate level phosphorylation occurs when a high energy molecule transfers a phosphate onto ADP to make ATP which is exactly what you have seen here.

    00:44 Now many people think mistakenly that this is the way most ATPs is made in the cell, by simply having a high energy molecule to transfer.

    00:54 It doesn't occur that way. And in fact most of the ATP in cells is made by a process called oxidative phosphorylation.

    01:01 This is an unusual reaction in a sense that ATP is made directly.

    01:07 We will see another one of those later in glycolysis.

    01:09 The delta G zero prime for this reaction is very energetically favorable, meaning -18.9 kJ/mol. It moves very strongly to the right and since we are making an ATP what that tells us is that there is a lot energy in 1,3-bisphophoglycerate in order to make this happen so efficiently.

    About the Lecture

    The lecture Glycolysis: 1,3 BPG –> 3-PG – Glycolysis and Pyruvate Metabolism by Kevin Ahern, PhD is from the course Carbohydrate Metabolism.

    Included Quiz Questions

    1. This reaction is called a substrate-level phosphorylation.
    2. This reaction is catalyzed by phosphoglycerate mutase.
    3. This reaction is the only oxidation reaction in glycolysis.
    4. This reaction is not very energetically favorable.
    5. This reaction is how most ATP is formed in the cell.

    Author of lecture Glycolysis: 1,3 BPG –> 3-PG – Glycolysis and Pyruvate Metabolism

     Kevin Ahern, PhD

    Kevin Ahern, PhD

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