Lectures

Gestational Trophoblastic Disease (GTD)

by Carlo Raj, MD
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    00:01 Let’s move on to choriocarcinoma.

    00:03 It’s a malignant neoplasm of trophoblastic cells.

    00:06 It can be preceded by hydatidiform mole, 50% of the time, which one? Complete or partial, please? Use the C’s.

    00:15 A complete mole may go on to greater risk of choriocarcinoma.

    00:19 Before we move on though, I very much wish to remind you that you can have gestational choriocarcinoma and don’t get this confused.

    00:28 Once again reinforce this, so clearly you are going to organize your thoughts.

    00:33 Gestational choriocarcinoma, non-gestational choriocarcinoma.

    00:37 So when you say non-gestational choriocarcinoma, what organ are you then affecting in a male or female? Gonads.

    00:45 Gonads.

    00:46 Remember when we talked about germ cell tumors and your gonadal tumors of a male or female.

    00:51 Well, choriocarcinoma can be part of that.

    00:54 It’s non-gestational.

    00:55 Here, however, gestational.

    00:58 What else? Abortion of ectopic, possibility of going onto choriocarcinoma.

    01:03 Even normal term pregnancy has a risk of 30%.

    01:08 Not impossible to monitor development of trophoblastic disease because you’re actually monitoring the hCG.

    01:14 So the more that you have proliferation of your trophoblast, you’d find there to be a correlation with beta-hCG.

    01:22 Unfortunately, with choriocarcinoma, it’s early.

    01:25 Remember, this is a cancer and this is carcinoma that likes to go through the blood.

    01:30 So there will be early hematogenous spread.

    01:33 And it’s responsive to chemotherapy, thank goodness.


    About the Lecture

    The lecture Gestational Trophoblastic Disease (GTD) by Carlo Raj, MD is from the course Pregnancy Complications.


    Included Quiz Questions

    1. Complete hydatiform mole
    2. Partial hydatiform mole
    3. Puberty
    4. Normal term pregnancy
    5. Abortion of ectopic pregnancy
    1. Nongestational choriocarcinoma occurs in the uterus.
    2. Disease development may be monitored by serum beta-hCG.
    3. It is responsive to chemotherapy.
    4. It tends to spread hematogenously early in the disease course.
    5. It is a malignant neoplasm of trophoblastic cells.

    Author of lecture Gestational Trophoblastic Disease (GTD)

     Carlo Raj, MD

    Carlo Raj, MD


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