Genetic Variation: Responsible Factors

by Georgina Cornwall, PhD

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    Now, it’s time to take a step back from the Hardy-Weinberg equation itself. Think again about this Hardy-Weinberg equilibrium because as I mentioned and as we know, it’s not a very realistic situation. Because it’s not very realistic, we can use it as a measure to compare reality against. But what happens when they can’t be met? What do we call these situations? You probably already have an idea that we break pretty much all of the Hardy-Weinberg assumptions, right? We know that mating is not always random. For example, in the United States, we may have stratification in which there’s different cultural groups that associate together and marry within their culture, different ethnic groups. We also have somewhat of a hierarchy of class structure where it may be more common to marry within your group than outside of your group which is actually selective mating. It’s certainly not random mating as if running into any old person would really work out, right? Assortative mating is what we actually do in reality. We have positive assortative mating and negative assortative mating. This is a really interesting field all on its own, to consider that some individuals are more likely to positively assort, like brings like and other individuals are more likely to negatively assort and mate with someone opposite of themselves. Both of those provide their role when we consider population genetics. I think it’s a fascinating field. But we can increase diversity by outbreeding, so to speak and negative assortative mating. But positive assortative mating is usually what happens. We mate within our groups. Of course, we can take that to an extreme, consanguinity where we have on occasion, mating within families. Either way, I’m just covering this because they are forces that move us away from completely random...

    About the Lecture

    The lecture Genetic Variation: Responsible Factors by Georgina Cornwall, PhD is from the course Population Genetics. It contains the following chapters:

    • Factors Responsible for Genetic Variation
    • Mutation
    • Natural Selection
    • Gene Flow
    • Genetic Drift - Founder Effect

    Author of lecture Genetic Variation: Responsible Factors

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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