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Frank-Starling Curve and Atrial Dynamics – Cardiac Mechanics

by Thad Wilson, PhD
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    Let's summarize a number of the changes that happen on the Frank-Starling curve. This will allow us to bring concepts together because we know they’re hard. But if we review them again, we’ll be able to gain better insight into them. And as you see them change in close proximity, you’ll be able to comprehend all the different changes that happen because, remember, nothing ever changes in isolation. So, let's go through those. And increase in preload, you travel along the same curve, but just two upward points. A decrease preload, use the same curve again. But now, you're going down in the curve, which means you're at a lower left ventricular end-diastolic pressure. If you have an increase in inotropy or a decrease in afterload, you shift the whole curve to the left and upwards a little bit. That means per amount of left ventricular end-diastolic pressure you’re going to get a greater stroke volume. If you have an increase in afterload or a decrease in inotropy you get a shift in which the curve moves downward and to the right. This means that at any given left ventricular end-diastolic pressure you’re going to have a lower stroke volume. Now, let's really dive in to these interrelationships because there are certain times that the body is going to change multiple things at the same time. So, let's take a good example that is a fight or flight response. This is something where your body is going to have to respond to something and runaway. To be able to do that, you're going to have to increase your cardiac output. So how are you going to do it? Well, there are a couple of mechanisms that you can start with. The first mechanism that you’re going to go through here...

    About the Lecture

    The lecture Frank-Starling Curve and Atrial Dynamics – Cardiac Mechanics by Thad Wilson, PhD is from the course Cardiac Physiology.


    Included Quiz Questions

    1. Increased preload
    2. Increased afterload
    3. Decreased inotropy
    4. Decreased cardiac contractility
    1. An increase in venous return
    2. A decrease in sympathetic nervous system stimulation
    3. A decrease in parasympathetic nervous system stimulation
    4. An increase in premature ventricular contractions

    Author of lecture Frank-Starling Curve and Atrial Dynamics – Cardiac Mechanics

     Thad Wilson, PhD

    Thad Wilson, PhD


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    By sarah F. on 18. May 2017 for Frank-Starling Curve and Atrial Dynamics – Cardiac Mechanics

    I enjoyed the breakdown of each intricate part of the system. I feel that I understand pharmacology better, especially digoxin and its effect on the heart.