Frameshift Mutations

by Georgina Cornwall, PhD

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    About the Lecture

    The lecture Frameshift Mutations by Georgina Cornwall, PhD is from the course DNA Repair & Genetic Mutations.

    Included Quiz Questions

    1. A small deletion has removed the nucleotides that code for the signal sequence at the amino terminus of the protein.
    2. A missense mutation has caused premature termination during translation of this protein.
    3. A chromosomal segment that includes the gene for insulin has been inverted.
    4. A two-base deletion near the middle of the gene has altered the reading frame during translation of the protein.
    5. A missense mutation has altered the ribosome-binding sequence at the 5' end of the mRNA.
    1. Huntington’s disease leads to the degeneration of excretory and digestive systems due to heavy metal toxicity.
    2. The trinucleotide repeat expansions in genes or introns lead to triplet repeat expansion disorders.
    3. The expanded CAG repeats in the coding regions get translated into a polyglutamine tract ("polyQ") which leads to an increased aggregation.
    4. The expanded CAG repeats in the coding regions of few proteins lead to few neurologic disorders in humans.
    5. Few of the codon reiteration disorders fall under the category of insertion mutations.

    Author of lecture Frameshift Mutations

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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