Fibrocystic Breast Change

by Carlo Raj, MD

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    Our first topic here will be fibrocystic change, extremely important. Understand that we do not call this a disease and this definitely not a cancer. So two things that I’ve said here that is of utmost importance. Number one, it’s not a disease. It’s a change. Number two, it is not cancer. Learn that first. Why am I not calling it a disease? Approximately 50% of females in the reproductive age have this going on. Fibrocystic change. Thank goodness this isn’t breast cancer. In fact, the chance of going on to breast cancer are quite slim. Okay, it’s a change, not a disease. I’m not going to call this a tumor 50% of population. Young and we’ll talk about different histologic manifestations. Know this really well and, as a point of reference, you need to compare this with an important differential called an actual benign tumor and that will be a fibroadenoma. So in case your breast pathology is weak, I am going to give you the pinpoint diseases and differentials that you must know for the boards and before you walk into the wards. Diagnosed frequency: young female, 20 to 40. This would indicate reproductive age, right? Number two, what I’ll also do with you as we go through this is how we differentiate this from fibroadenoma. Guess what? A fibroadenoma found in a female would be pretty much in the same age range. So right now, there’s nothing distinguishing one from the other, but at least you have two differentials. Move on. There might be hormonal imbalances. You’ll find this fibrocystic change. You’ll find this with fibroadenoma. One is a tumor and one is not. Is fibrocystic change a tumor? No, it’s not. Is it a disease? No, it’s not. Will it go on to cancer? Not particularly....

    About the Lecture

    The lecture Fibrocystic Breast Change by Carlo Raj, MD is from the course Breast Disease. It contains the following chapters:

    • Fibrocystic Change
    • Clinical Features of Fibrocystic Change
    • Morphology of Fibrocystic Change

    Included Quiz Questions

    1. Mid-cycle LH surge
    2. Menstruation
    3. Luteal phase
    4. Secretory phase
    5. Proliferative phase
    1. Negative feedback for endogenous estrogen production
    2. Increased circulating levels of estrogen
    3. Suppression of lactation
    4. Suppression of ovulation and resulting progesterone release
    5. Increased circulating levels of progesterone
    1. Purulent nipple discharge
    2. Palpable lumps
    3. Clear nipple discharge
    4. Mammographic calcification
    5. Bloody nipple discharge
    1. Cysts are always filled with fluid.
    2. They are true cysts.
    3. Cysts may resemble a bruise on the breast.
    4. They are lined by epithelium.
    5. They are associated with apocrine metaplasia.

    Author of lecture Fibrocystic Breast Change

     Carlo Raj, MD

    Carlo Raj, MD

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