HMPCC associated with hereditary nonpolyposis syndrome.
That is the one which where we talked about when you have right colorectal cancer.
Meaning of FAP, familial adenomatous polyposis. Autosomal dominant.
It is a carpet of polyps. This is a young patient
and there is going to be 100% chance of going on to colorectal cancer.
Screening for all members and you do prophylactic colectomy
because you know your patient is going on to colorectal cancer. What kind?
Left sided. Memorize that, if you haven?t all ready.
The full molecular talk about a neoplasia.
Once again, familial adenomatous polyposis.
You must know about APC, adenomatous polyposis coli,
which then controls your beta-catenin. And if your APC has been lost,
your beta-catenin is an opposed and brings about excessive transcription.
With all that transcriptions taking place within your intestinal epithelial cell,
you can only imagine that you are going to form carpets of polyps.
APC, beta-catenin and WMT, all properly regulate your growth
and proliferation of your epithelial cell.
If it is FAP and you have other associations for example,
if it is going to be extra intestinal referring to your: S, sebaceous on your skin,
O, osteoma a benign bone tumor; D, desmoid and that would be a fibroma
and now you called this Gardner?s syndrome.
Gardner?s syndrome. If you have FAP associated with Turcot, C as in Turcot,
you may use this with CCNS, a glioma.
So you have FAP plus a glioma, you call this Turcot,
if you have FAP with your sebaceous osteoma and desmoid,
this is then known as your Gardner.
If you forgotten any component that I have just mention here, for either of the two,
please repeat what I just said and make sure that you have firmly implanted
those facts into your head.
So that you know the variants of your familial adenomatous polyposis.
All of these would be hereditary polyposis syndrome.
Hereby if you're nonpolyposis also also called Lynch and with HNPCC,
this will be on the right side and you have ovarian issues as well.
Take a look at this. We have a carpet of polyps, either with a colonoscopy,
where you find so many polyps and then you open up the colon
and when you do so, you find a carpet of polyps on your right.
Hence, 100% risks of going all to colorectal cancer.
This has nothing to do, in by that I mean the following.
You are not going to waste your time trying to figure out what kind of polyp,
when he haves so many different polyps, a hundreds and thousands of them.
You're going on to colorectal cancer. So take it out. Don?t waste time.
Whereas if you have individual polyps,
that's when you start paying attention to, is this villous or tubular.
Villous or tubular? If it's tubular, it still will be taken out.
You clip it, but the risk of going on to colorectal cancer technically is decreased.
Whereas if it's villous, it's the villain, at flat, but it does not being shown here.
But that has an increase risk of colorectal cancer.