Extra-Intestinal Manifestations of Inflammatory Bowel Disease (IBD)

00:01 Gastrointestinal manifestations in totality of Inflammatory Bowel Disease.

00:05 For full joint activity mirrors that of inflammatory bowel disease activity, that`s important.

00:12 The more that you have joint activity, the more that inflammatory bowel disease is pronounced in your patient.

00:18 The skin lesion here from inflammatory bowel disease known as erythema nodosum, also pyoderma gangrenosum.

00:27 One would think with that name that back to infection.

00:29 No. Poorly named pyoderma gangrenosum, lots of neutrophils, I´ll give you that And aphthous ulcers maybe up in the mouth region but really could be anywhere.

00:43 Eye lesions: Uveitis, episcleritis, one thing that I wish to make sure remind you, is skin lesion and if you´re dealing with Celiac´s disease that´s known as your dermatitis herpetoformis.

00:57 With inflammatory bowel disease and especially ulcerative colitis would be primary sclerosing cholangitis.

01:11 The fact that you´re referring to as cholangial and lesion to it, then the marker that you´re using here is called Alk phos (Alkaline phosphatase).

01:22 Axial symptoms here, HLA-B27 like, so therefore here you go.

01:31 You have ankylosing spondylitis and company and please do not forget, once again, primary sclerosing cholangitis (involvement of the gall bladder, huh?) And this is no joke? That, primary sclerosing cholangitis is associated with cholangic carcinoma as you have a progressive course.

01:53 A skin lesion that we`re looking at here is no joke.

01:59 This pyoderma gangrenosum, one would think this is a bacterial infection and there is something going on here in terms of like I said, is there an infection taking place? No.

02:11 This is an extraintestinal manifestation of inflammatory bowel disease, pyoderma gangrenosum.