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Endoplasmic Reticulum and Golgi Apparatus
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Slides 06 CellularStructure CellBiology.pdf
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Reference List Molecular and Cell Biology.pdf
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Download Lecture Overview
00:00 Closer look at each of the components of this endomembrane system, endomembrane transport system. 00:06 The first piece recall is the endoplasmic reticulum. I've always loved that word. 00:11 It has two components. We've got the smooth and the rough endoplasmic reticulum. 00:19 The rough endoplasmic reticulum is rough because it has ribosomes on it. 00:24 Because it has ribosomes on it, we know it's associated with the manufature of proteins and these are manufacturing proteins to go. The other component is the smooth endoplasmic reticulum. 00:37 And the smooth endoplasmic reticulum has a little bit different of a function. 00:42 It can produce lots of membrane because it is made of phospholipids. Recall, all of these endomembrane system is phospholipid bilayer. 00:51 A single layer now. But phospholipid bilayer nonetheless. 00:55 And so the smooth endoplasmic reticulum can produce a lot of itself and it's actually also involved in detoxification. 01:04 So for example, a liver cell would have a lot of smooth endoplasmic reticulum because it's involved in detoxification. 01:12 You can actually see after a big night on the town, or perhaps you've had one or too many cocktails, the liver cells will produce extra endoplasmic reticulum. And on the micrograph you can see that, and we call that fatty liver. 01:28 So extra alcohol consumption, extra detoxification necessary, lots more endoplasmic reticulum. 01:35 So moving on from there, we see the Golgi apparatus is the next step in the game. 01:42 We said this is the shipping center. Again it has a cis face and a trans face The cis face is the arrival side, that's where you are dropping off your packages that you've just made in your production center. 01:56 We drop off the packages on one side, and they are taken in by endocytosis, the materials are pulled into the Golgi apparatus. 02:06 And then they are repackaged and labelled and addressed and put in the correct vans to be sent out on the trans face. 02:15 I do remember those because trans is about transport, transporting away. 02:19 And cis, well, that's arrival, because it's not transport. 02:23 And then we end up having our vesicle, which is our little van. Van, vesicles, going all the way to the external cell membrane and we will drop off the contents of the cell on the external cell membrane.
About the Lecture
The lecture Endoplasmic Reticulum and Golgi Apparatus by Georgina Cornwall, PhD is from the course Cellular Structure.
Included Quiz Questions
Which statement is INCORRECT regarding the endoplasmic reticulum?
- The smooth endoplasmic reticulum of pancreatic secretory cells helps in the synthesis of digestive enzymes.
- The rough endoplasmic reticulum has a rough surface due to the presence of ribosomes, whereas the smooth endoplasmic reticulum lacks ribosomes.
- Hepatocytes have abundant smooth endoplasmic reticulum that can detoxify and inactivate toxins.
- Smooth endoplasmic reticulum can synthesize membranes due to its high phospholipid content.
- Rough endoplasmic reticulum is the main manufacturing center for secretory proteins such as enzymes and hormones.
Which of the following describes the function of the Golgi apparatus?
- It receives proteins from the endoplasmic reticulum, modifies and sorts them, and finally packs them for secretion by the secretory vesicles.
- It receives mRNA from the nucleus, modifies it, and finally packs it for dispatch to the ribosomes.
- It helps assemble a fully functional protein-synthesis machinery around the mature mRNA molecule.
- It receives tRNA from the nucleus and combines them with ribosomes to commence translation.
- It receives rRNA from the nucleus and combines them with proteins to create a fully functional ribosome.
Author of lecture Endoplasmic Reticulum and Golgi Apparatus
Georgina Cornwall, PhD
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The most important part of this lecture in my opinion is the analogies that Dr. Georgina offers. It really help us to understand for example when she associated the Golgi Complex with a Fedex facility, or when she connects the fact that liver cells have more SER since one of its important functions is detoxification.
I really enjoyed the video and it made me learn, also I liked that are short videos
