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Introduction esp. Types of Eliminations – Elimination Kinetics

by Pravin Shukle, MD
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    Welcome to pharmacology by Lecturio. Today's lecture is about elimination kinetics, how we get rid of drugs that are already in our body. My name is Dr. P.J. Shukle, I will take you through this journey, and hopefully we can learn something together. Let's talk about kinetics and the different type of elimination kinetics that occur. Zero order kinetics is a constant rate of elimination. You can see that the concentration is very consistently going down over time. It is irrespective of the concentration, so the slope is not changing at all on this graph. First order kinetics is a changing rate of elimination. So, you can see that as we get lower and lower in terms of our concentration, you're getting rid of less and less of the drug. It is dependent upon concentration, and there's always a proportional decrease. Now, we have mixed kinetics in the real world, so you can see that there's actually two different slopes to this particular graph. So the first part of this slope is the initial distribution phase. That represents drug moving from the blood into the tissues. This is very rapid and it tends to be what we called zero order kinetics. The second portion of this curve is the elimination phase representing the removal of the drug. This tends to be a bit slower, and once again, for this particular drug, it's zero order kinetics. We can have multiple mixtures depending on the individual drugs. The half life is a very important concept that we want to understand when we are looking at drugs. It is the time whether it's hours, minutes or a day, at which the mass or total amount of unchanged drug becomes half of the original concentration. So, this for example, is an example of a...

    About the Lecture

    The lecture Introduction esp. Types of Eliminations – Elimination Kinetics by Pravin Shukle, MD is from the course Pharmacokinetics and Pharmacodynamics. It contains the following chapters:

    • Introductions to Kinetics
    • Questions: Reviewing Kintetics

    Included Quiz Questions

    1. The first phase of mixed distribution refers to the movement of drug from blood to tissue.
    2. The first phase of mixed distribution refers to the movement of drug from blood to the urine.
    3. The first phase of mixed distribution refers to the movement of drug from blood to bile.
    4. The first phase of mixed distribution refers to the movement of drug from blood to the feces.

    Author of lecture Introduction esp. Types of Eliminations – Elimination Kinetics

     Pravin Shukle, MD

    Pravin Shukle, MD


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