00:01 When you look at other forces all over the world, whether they be military, paramilitary or police, you see the similar kind of guidelines being put forward. 00:10 Where do they come up with these guidelines and what are they basing it on? Well, let's take a look at defined medically confirmed effects of unrefined marijuana which isn't, let's say a joint. 00:24 Between 30 and 120 minutes of ingestion, you'll have a change in perception. 00:29 Patients will often complain of a dry mouth. 00:31 There are decreased motor skills that are measurable in standardized testing. 00:36 Patients will have red eyes due to capillary dilatation in the sclera. 00:40 Patients will often have a heightened mood, so they feel better. 00:44 They are generally happier. 00:46 There is often an increased appetite. 00:48 So, this is something that has been seen as a benefit or a boon in patients who have cancer who are traditionally losing weight. 00:55 There's also a decrease in short-term memory which tends to be relatively transient. 01:01 After around two days to 12 days of ingestion, patients have measurable, definable, decreased mental processing. 01:10 They will also have decreased intelligence and problem solving on standardized testing. 01:15 And motor skill impairment will be much more prevalent, much more severe and can be permanent. So - and I want to stress this. 01:24 After 12 days of usage in de novo patients with marijuana utilization, they may have permanent motor skill impairment after only 12 days of use. 01:36 From 12 to 20 days, you start to see increasing paranoia and increasing anxiety. 01:41 This is despite the fact that some patients may actually have been using their marijuana to treat paranoia and to treat anxiety. 01:49 So after an initial benefit in anti-anxiety activity, there is an increase anxiety overall. 01:56 There is often seen an unmasking of schizophrenia. 01:59 And this is probably the worst aspect of marijuana consumption, is the unmasking of normal patients with schizophrenia. 02:07 And the schizophrenia can be quite severe to the point where they become violent. 02:11 I also want to point out that this unmasking may be permanent. 02:14 We don't know yet, but we have seen patients who have had normal lives up until the consumption of marijuana. 02:21 And after the consumption of marijuana, they become schizophrenic, and the schizophrenic has been permanent and it's absolutely ruined their lives. 02:31 We also have seen some unmasking of psychotic behavior. 02:34 So after the initial high - in between highs, these patients can be quite violent and can be prone to impulsivity. 02:43 We've also seen a tremendous increase in the unmasking of depression. 02:46 And in particular, we're seeing this in young patients under the age of 25. 02:51 Of course we see decreased mental activity. 02:53 There's a 20% reduction in information process - processing based on standardized testing using complex processing testing equipment. 03:03 Finally, there are reduced maladaptive responses. 03:06 What do I mean by that? If a patient experiences a death in the family for example, their ability to cope with that particular death is much more dramatic and much less reasonable than in a patient who doesn't smoke marijuana on a regular basis. 03:23 So the coping skills are actually reduced and there's maladaptive responses that are impaired in those patients. 03:31 Patients who are smoking for 20 to 720 days have selective attention reduction in their skill set. 03:40 And they also have concentration reduction so people are less able to complete complex tasks. 03:46 Light users. Not heavy users, but light years, defined as less than two joints a week have reduced hypothesis testing skills, have reduced conceptualizing of difficult tasks and ideas, have reduced inhibition, have reduced impulsivity. I'll explain those two in a second. 04:04 10 to 30% reduction in intelligence and 12% reduction in language processing. 04:11 Now, two of those seem to be a bit contradictory. 04:14 On the one hand you have reduced inhibition. 04:17 On the other hand, you have reduced impulsivity. 04:19 What does that mean? Reduced inhibition means that they are more prone to suggestion. 04:25 So if a person suggests, you know, "Let's go here or lets go there," there is reduced inhibition to doing so. 04:31 But on the other hand, the idea that they're going to get up and do it themselves is reduced as well. 04:36 So that impulsivity, that's self-directed means of getting up and doing something is reduced. 04:42 So it seems like a contradictory set of behaviors. 04:47 But when you realize that these are both due to a reduction in the same area of the brain, it starts to make a little bit of sense. 04:57 The very long term side effects of unrefined marijuana. 05:00 Psychosis, including the unmasking of those diseases. More schizophrenia and more unmasking. 05:06 More depression and an increase in suicide risk. 05:09 Some studies in the British medical Journal have shown a 3 to 5-fold increase risk of suicide in young people under the age of 25 with only one year of marijuana usage. 05:22 The use of low-dose pot when we're talking only once a week with discontinuation prior to age 25. 05:30 So what we did was we compared kids who had smoked pot, say for example between the ages of 16 and 21 and then stopped. 05:39 And we compared those kids to their age match controls who did not take part in smoking pot and we found some shocking evidence. 05:49 And this was reported in - also in the British medical Journal. 05:52 There was a threefold increase in depression rates. 05:54 There was an increase in anhedonia which means that they enjoyed things less. 06:00 There is a threefold increase in the risk of suicide and there is permanent reduction in brain development. 06:06 And in another study done in America, it actually showed a reduction in the folds of the brain on MRI scanning.
The lecture Effects of Unrefined Marijuana – Drugs of Abuse by Pravin Shukle, MD is from the course Toxicology.
What is an acute neuropsychiatric effect of cannabis intoxication?
A 20-year-old male smokes a joint of marijuana. Shortly afterward, he experiences dry mouth, mild euphoria, and impairment of short-term memory. He also develops mild anxiety. Which of the following acute side effects would be least likely to occur after smoking a single joint of marijuana?
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