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The lecture pKa and Drug Solubility – Absorption and Distribution | Pharmacokinetics (PK) by Pravin Shukle, MD is from the course Pharmacokinetics and Pharmacodynamics.
Included Quiz Questions
A 44-year-old woman presents to the hospital ER with a low blood pressure of 77/40, a heart rate of 40, and normal pupils. She has an empty bottle of blood pressure pills that have a pKa of 7.5. In addition to hemodynamically supporting the patient, you want the patient to excrete the drug in the urine. Theoretically, of the following choices, what would be the most appropriate action?
- Acidify the urine. This will protonate the drug, allowing it to be more soluble in the urine.
- Alkalinize the urine. This will protonate the drug, allowing it to be more soluble in the urine.
- Alkalinize the urine. This will deprotonate the drug, allowing it to be more soluble in the urine.
- Acidify the urine. This will deprotonate the drug, allowing it to be more soluble in the urine.
A 5-year-old child overdoses on her mother's anti-depression medications. The pKa of the drug is 3.9. The pH of the small bowel is 5.9. What percentage of the drug is potentially absorbable across the lipid membrane?
- 1%
- 99%
- 100%
- 10%
- 90%
A patient has overdosed on pyrimethamine, with a pKa of 7.42. What percentage of the drug will be trapped in the urine if the urine pH is 5.42?
- 99%
- 90%
- 9%
- 1%
A patient has overdosed on pyrimethamine. It has a pKa of 7.42. What portion of the drug will be hydrophilic at a urine pH of 8.42?
- 10%
- 90%
- 9%
- 1%
- 99%
Author of lecture pKa and Drug Solubility – Absorption and Distribution | Pharmacokinetics (PK)
Pravin Shukle, MD
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He is very good excellent clearly understand the lecture pharmacology aesthetic