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Drug Metabolism – Biotransformation | Pharmacokinetics (PK)

by Pravin Shukle, MD
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    About the Lecture

    The lecture Drug Metabolism – Biotransformation | Pharmacokinetics (PK) by Pravin Shukle, MD is from the course Pharmacokinetics and Pharmacodynamics. It contains the following chapters:

    • Metabolism of Drugs
    • Cytochrome P450
    • 3 Phases of Metabolism
    • Question: Biotransformation

    Included Quiz Questions

    1. ..will make the drug more hydrophilic, through a phase II (phase 2) process.
    2. ..will make the drug more hydrophilic through a phase III (phase 3) process.
    3. ..will make the drug more hydrophilic through a phase I (phase 1) process.
    1. Used in the excretion of drugs or toxins into the bile or other fluids, utilizing P-glycoprotiens.
    2. Useful to excrete drugs into the bile by adding glutathione to the drug or toxin, making it more water soluble.
    3. Useful to excrete drugs into the bile by adding a methyl group to the drug or toxin, making it more water soluble.
    4. Often used to inhibit the MDR-1 gene.
    1. Liver
    2. Bones
    3. CYP450 activity occurs in all the tissue types.
    4. Red blood cells
    5. Muscles
    1. -MDR1
    2. -OH
    3. -glycine
    4. -NH2
    5. -SH
    1. Make the drug more hydrophilic.
    2. Make the drug more hydrophobic.
    3. Increase the volume of distribution.
    4. Removing a polar group.
    5. Masking a polar group.

    Author of lecture Drug Metabolism – Biotransformation | Pharmacokinetics (PK)

     Pravin Shukle, MD

    Pravin Shukle, MD


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    By Mariana Z. on 09. January 2018 for Drug Metabolism – Biotransformation | Pharmacokinetics (PK)

    Best pharmacology classes! Love the questions in between the lecture!