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Drug Distribution – Absorption and Distribution | Pharmacokinetics (PK)

by Pravin Shukle, MD
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    Here is a case study, compound C. A 25 year old takes compound C. Levels were measured and found to be 300ng/ml. The volume of distribution is 100L. How much C was ingested? Okay so this is an interesting question because we start to introduce concepts of volume of distribution. The answers here are clearly somehow calculated and give you an answer with a 3 in it. The qestion is, what is the answer. Okay, what's the volume of distribution. The volume of distribution is the amount of drug in the body divided by the concentration in the blood. Now that sounds kind of complicated but let me explain it to you with some pictures. So let's take a look at drug A. We put drug A into the blood and after it diffuses across various membranes, you have 2 units of drug A in the blood or the vascular compartment. And you have 18 units of drug A in the extravascular compartments. Let's say it's in the tissues or in the interstitial tissues. Okay, what's the volume of distribution here? Well there is 2 units in the blood and there is 20 units overall. So the volume of distribution is 20 divided by 2 or 10. It's in litres so it's 10L. So, when you think about it it's as if you have 10L of blood. You and I both know that we each have 6L or 7L of blood in our body. But it's as if with the way that the drug is moving that we have 10L of blood. Okay, let's take a look at drug B. This is a different kind of a drug because now it's being bound to a blood protein. You can see that it's all almost all in the blood compartment bound...

    About the Lecture

    The lecture Drug Distribution – Absorption and Distribution | Pharmacokinetics (PK) by Pravin Shukle, MD is from the course Pharmacokinetics and Pharmacodynamics. It contains the following chapters:

    • Distribution of Drugs
    • Case Study: Sick woman in the ICU

    Included Quiz Questions

    1. 400 mg/l
    2. 40 mg/l
    3. 25 mg/l
    4. 2.5 g/l
    1. The dose is appropriate, at 0.2%.
    2. The dose is toxic, with a concentration of 2%
    3. The dose is toxic, with a concentration of 5%
    4. The dose is toxic, with a concentration of 0.5%
    1. 200 mg/litre
    2. 1 g/litre
    3. 50 g/litre
    4. 50 mg/litre

    Author of lecture Drug Distribution – Absorption and Distribution | Pharmacokinetics (PK)

     Pravin Shukle, MD

    Pravin Shukle, MD


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