DNA Virus – Carcinogenesis

by Carlo Raj, MD

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    At this juncture, you may want to take a look at that flow chart that I began our discussion with. Do not lose sight of what we are trying to accomplish. Our objective for that flow chart was to take a normal cell, and then upon exposure various elements such as chemicals that I walked you through including arsenics such as chromium, such as nitrosamines so on and so forth. The patient may develop a cancer or if the patient is being exposed to certain viruses here may develop cancer. Let's talk about HPV now. Our topic is a DNA virus that the patient has been exposed to and, he or she, develops cancer. Now HPV is a big deal. Listen. With HPV you should be thinking about sexually transmitted infection right, STI. With HPV could be male or female put them both together. And with HPV you should be thinking about the higher strains not the lower. My topic is cancer. HPV 16,18,31 and 33. And with HPV, in a female you begin with the following. There might be vulva issues. So there might be squamous cell cancer of the vulva. You keep going. There might be issues within the vagina and in the cervix. Would you tell me the part of the cervix that's facing you. Meaning, facing you as a clinician when you do a pelvic exam. That's the exocervix. What kind of cells is your exocervix? Squamous. There you are in the transformation zone. Are you there? Put yourself in the cervix, the transformation zone. That which is facing the external world, exocervix is squamous. That which is facing the uterus, endocervix is the columnar. That's your transformation zone. Now you tell me quickly what is it within the vagina that allows for the cells to...

    About the Lecture

    The lecture DNA Virus – Carcinogenesis by Carlo Raj, MD is from the course Cellular Pathology: Basic Principles.

    Included Quiz Questions

    1. HPV 16, 18
    2. HPV 6, 11
    3. HBV 16, 18
    4. EBV
    5. HPV 32, 34
    1. Liver carcinoma
    2. Burkitt lymphoma
    3. B cell lymphoma
    4. Hodgkin disease
    5. Nasopharyngeal carcinoma
    1. CD21
    2. Nasopharyngeal epithelium
    3. EBV viral receptor
    4. Damaged B cell receptors
    5. CD14
    1. HTLV-1
    2. EBV
    3. Hepatitis C
    4. H. pylori
    5. HPV 16, 18
    1. Gastric carcinoma
    2. T cell lymphoma
    3. Liver cancer
    4. Hodgkin disease
    5. Nasopharyngeal carcinoma

    Author of lecture DNA Virus – Carcinogenesis

     Carlo Raj, MD

    Carlo Raj, MD

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