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DNA Repair Defects & Neoplastic Molecular Markers – Carcinogenesis

by Carlo Raj, MD
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    You'll notice here, on the flow chart thus far, we've walked through our box on the left in which we talked about chemicals, viruses and radiation. When a normal cell has been exposed increases the risk of carcinogens. Our next topic, which is a very short topic is that if there is failure of your DNA repair which we already kind of discussed with xeroderma pigmentosa. Upon exposure to UVB rays may then develop cancer. DNA repair defects. Let's talk about this in great detail. What you find here on the right, is the fact that you have your DNA, and you have a double helix. Next, you find depurination and then you have a, what's known as a endonuclease. And then finally DNA polymerase in which it then helps you put back a part of the strand which is then been removed. You'll notice here please, that on the bottom strip, from 5' to 3', that you have a nucleotide endonuclease taking out the G. And then you have a polymerase and along with the ligase which puts it all together. Now what ends up happening on the right, is the fact that you are not able to properly do it. Deaminase. Then you have DNA glycosylase. Then you have endonuclease and DNA polymerase. So these are the enzymes that you want to know, in general from genetics. I'm not going to go into greater detail about this apart from the fact that some of this enzymes may then become mutated. Mistakes made in DNA replication are corrected by DNA repair genes usually. Often detected by what's known as microsatellite instability. What is a microsatellite instability and why do you want to know this. If you are not able to properly remove a microsatellite instability, you might develop a...

    About the Lecture

    The lecture DNA Repair Defects & Neoplastic Molecular Markers – Carcinogenesis by Carlo Raj, MD is from the course Cellular Pathology: Basic Principles.


    Included Quiz Questions

    1. Deiodinase
    2. Deaminase
    3. DNA glycosylase
    4. Endonuclease
    5. DNA polymerase
    1. MSH2 and MLH1 mutations
    2. Thymine dimer mutation
    3. t(8:14)
    4. C-myc mutation
    5. Rb mutation
    1. BAX
    2. ERBB2
    3. RAS
    4. ABL
    5. MYC
    1. t(9;22)
    2. t(8;14)
    3. t(15;17)
    4. t(14;18)
    5. t(9;12)
    1. RAS
    2. ERBB2
    3. N-MYC
    4. MYC
    5. ABL

    Author of lecture DNA Repair Defects & Neoplastic Molecular Markers – Carcinogenesis

     Carlo Raj, MD

    Carlo Raj, MD


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