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Diversity of Major Histocompatibility Complex – Antigen Processing and Presentation

by Peter Delves, PhD
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    I’ve already mentioned that the MHC is by far the most diverse set of genes in the human genome. So let’s take a few moments to explore this diversity. As you can see on this diagram, at the top you can see a bar that is labeled M. This is meant to represent the chromosome 6, which is where the MHC in human is that you’ve inherited from your mom. So M for maternal chromosome. And you can see that there are the HLA Class I genes - HLA-A, B and C, and the MHC Class II genes - HLA-DP, DQ, DR. And these genes, as we’ve already heard vary enormously from one individual to another. So you might be HLA-A1 or A2 or A3 or A4 and so forth. And you can see that this particular individual is HLA-A84. So that gene will be transcribed and the HLA-A84 molecule will be put on the surface of that cell. This individual has also inherited HLA-B8 variant; could have had B3, B27, B64, whatever from the mother, but in this case the mother’s gene that it’s inherited… this individual has inherited is B8. So it puts B8 on its surface. And likewise, on the maternal chromosome the variant of HLA-C is HLA-C17. Of course there are two chromosomes, one from the father and one from the mother. So at the bottom we have the paternal chromosome, from the father. And this individual has inherited from their father HLA-A2, HLA-B27; so they do have B27 but it’s come from the father rather than the mother, and HLA-C46. So those three molecules are put on the surface. So for each HLA type, A or B or C, we potentially have two different variants. Now it may be that sometimes, an individual is homozygous...

    About the Lecture

    The lecture Diversity of Major Histocompatibility Complex – Antigen Processing and Presentation by Peter Delves, PhD is from the course Adaptive Immune System.


    Included Quiz Questions

    1. HLA-C β chain
    2. HLA-A α chain
    3. HLA-DR β chain
    4. HLA-DQ α chain
    5. HLA-B α chain
    1. ...increases diversity.
    2. ...creates possible cross reactivity.
    3. ...is always redundant to protect against genetic defects.
    4. ...leads to one HLA type from one parent on each gene locus.
    5. ...results in expression of H-2 molecules.
    1. ...sequence does not vary between individuals.
    2. ...is likely to show heterozygous variants.
    3. ...is the most polymorphic region within the MHC gene locus.
    4. ...is inherited from the mother only.
    5. ...does not encode for a functional protein.

    Author of lecture Diversity of Major Histocompatibility Complex – Antigen Processing and Presentation

     Peter Delves, PhD

    Peter Delves, PhD


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    TOO MUCH DETAILS!
    By Jake Bryan C. on 17. January 2017 for Diversity of Major Histocompatibility Complex – Antigen Processing and Presentation

    Too many numbers and letters with no direct clinical correlation Too many details with no explicitly stated relevance Topics too segmented and poorly arranged I am lost...