Lectures

Direct and Indirect Alloantigen Recognition

by Peter Delves, PhD
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    About the Lecture

    The lecture Direct and Indirect Alloantigen Recognition by Peter Delves, PhD is from the course Transplantation Immunology. It contains the following chapters:

    • Direct and Indirect Alloantigen Recognition
    • Activation of Alloreactive T-Cells
    • The Immune Response to a Liver Graft

    Included Quiz Questions

    1. IL-2
    2. IL-4
    3. IL-10
    4. IL-12
    5. IL-13
    1. Allogeneic antigen presenting cells that express allogeneic MHC
    2. Autoreactive T-cells
    3. Memory T cells specific for allograft
    4. Allogeneic antigen presenting cells that express self MHC
    5. Self antigen presenting cells that express allogeneic MHC
    1. T cells become activated and CD4+ and CD8+ effector T cells targeting the alloantigen are produced
    2. Allogeneic effector T cells secrete cytokines which induce graft rejection
    3. CD4+ effector T cells become activated and travel to allograft- CD8+ cells are not involved
    4. Allogeneic APCs will activate self CD4+ effector T cells, mediating graft rejection
    5. Cytokines produced by allogeneic CD4+ cells will prevent invasion of CD4+ and CD8+ effector T cells from host
    1. Treg cells
    2. Complement activation
    3. IL-2
    4. IFNγ
    5. IL-1

    Author of lecture Direct and Indirect Alloantigen Recognition

     Peter Delves, PhD

    Peter Delves, PhD


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