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Lymphadenopathy: Diffuse Large B-Cell Lymphoma – White Blood Cell Pathology

by Carlo Raj, MD
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    A non-Hodgkin’s lymphoma, also very common, a diffuse large B-cell lymphoma. Here, officially, you will be responsible for at least three different ways in which your patient is going to develop diffuse large B-cell lymphoma. We officially have spoken and completed one possible method or progression and that’s from your follicular B cell lymphoma with translocation 14;18. A second that I briefly mentioned would be your Richter syndrome that then developed from CLL. With that said, 30% of your diffuse large B-cell lymphoma, where are you? Lymph node. With involvement of the lymph node, this will be the follicle and large replacement. You have large B-cells. In follicular lymphoma, in the follicle, these are small cleaved B-cells. These are large B-cells located in the follicle. Also, what I wish to mention here because at some point, when you have a discussion with an oncologist, they might be referring to diffuse large B-cell lymphoma of the GI. And that’s extranodal involvement of diffuse large B-cell lymphoma. I said extranodal because what category or family does DLBCL come under? It comes under non-Hodgkin’s lymphoma. Give me some common characteristics of non-Hodgkin’s lymphoma. What kind of spread in lymph node? Non-contiguous, non. And what about the involvement of extranodal sites, common or rare in NHL? Common. Commonly in the GI. 20-30% carry translocation and here’s your third type of development of your DLBCL. And this would be BCL-6, and that’s something that you absolutely must memorize. The gene involved in regulation of BCL differentiation, BCL-6, 14;18, and a third one that we will mention in going to greater detail, will be Richter syndrome. Diffuse large B-cell lymphoma is common in immunodeficient patients. Therefore, look for patients who may then develop diffuse large B-cell lymphoma with HIV involving both EBV or perhaps even HHV-8....

    About the Lecture

    The lecture Lymphadenopathy: Diffuse Large B-Cell Lymphoma – White Blood Cell Pathology by Carlo Raj, MD is from the course Lymphadenopathy – White Blood Cell Pathology (WBC).


    Included Quiz Questions

    1. Human herpesvirus 8
    2. Epstein-barr virus
    3. Kaposi sarcoma-associated herpesvirus
    4. Human papillomavirus
    5. Merkel cell polyomavirus
    1. 50-70
    2. 10-15
    3. 25-30
    4. 20-25
    5. 15-20

    Author of lecture Lymphadenopathy: Diffuse Large B-Cell Lymphoma – White Blood Cell Pathology

     Carlo Raj, MD

    Carlo Raj, MD


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