00:03
I think we've
wrapped up that case.
00:05
She's certainly going to
need a biopsy
to definitively identify
this lesion
and then decide
what type of tumor she has
and how to proceed.
00:14
Let's move on to
another case now.
00:17
This is a
58-year-old farmer
with a past medical history of
diabetes and hypertension
who's presenting
with a lesion
right on the tip of his nose
as shown here.
00:26
Now, he thought
it was a pimple
but he's noticed it growing
over the past six months
denies any pruritus.
00:33
Social and family history:
he's a non-smoker.
00:35
He spends, again, most of his day
in sun-exposed areas.
00:39
Review of systems
is unrevealing.
00:41
Initial vitals,
likewise unrevealing.
00:44
Now again, I want you
to try and describe
this skin lesion
without help from me.
00:52
The way I would describe this
again, this is a person
with fair complexion.
00:56
There is a single 1.5 centimeter
dome-shaped, pearly
translucent papule
on the tip of the nose
with visible telangiectasias.
01:08
Which of the following
is the most likely diagnosis?
Some of the same characters
we looked at before:
melanoma, keratoacanthoma
which we haven't talked about yet
seborrheic keratosis,
and then the non-melanoma skin cancers:
basal and squamous cell
carcinoma.
01:24
Now, you might be
thinking melanoma
that doesn't really look like
a melanoma on the tip of his nose.
01:30
But keep in mind, there are several
different subtypes of melanoma
including the nodular
subtype depicted here
that could certainly be
what he's got on his nose.
01:39
I think we have to keep that
on our differential
and only a biopsy will really give us
the answer for that one.
01:45
It's also important to keep in mind
epidemiology here.
01:50
Melanoma skin cancers
only represent 2% of skin cancers
and contrast basal cell
and squamous non-melanoma skin cancers
they are the vast
majority of skin cancers.
02:02
From a probability standpoint,
melanoma is probably not what's going on here.
02:05
But nonetheless,
it's such a severe diagnosis
especially if it's a nodular type
which has that vertical growth phase.
02:14
We have to be mindful of that
and look forward on biopsy.
02:18
But let's talk about
keratoacanthoma here for a moment
which is not really
a skin cancer per se.
02:24
It's been variably described
as either a pseudocancer
or at worst,
a low-grade malignancy.
02:31
It usually is on the face,
as is the case in our patient.
02:34
It occurs in elderly patients
over the age of 50.
02:37
It does have an association with HPV,
though not uniformly present.
02:42
One of the unusual things
about this lesion
is that it does have
a rapid growth phase.
02:47
You can be very concerned
that it could be cancer
because over the
span of weeks
you could go from having
a tiny, tiny little papule
to something that could be
a centimeter or two or even three in size.
02:57
Also interestingly,
it can spontaneously resolve.
03:00
It's a very unusual type of condition
and something to be aware of.
03:06
It mimics squamous cell
carcinoma in that way
the way that it appears
and the way that it can grow.
03:12
It has again a nodular,
dome-shaped, central keratotic plug.
03:17
Similar to what we're seeing
in our patient though
the central keratotic plug
is not something
that was described on exam
and not something that we're seeing.
03:25
Without that keratinized
central plug
I think we can take
keratoacanthoma off the list.
03:31
Now here again,
we're looking at seborrheic keratosis.
03:34
This again has this characteristic
stuck-on type of appearance
and it's often in
not sun-exposed areas.
03:42
Our patient has this lesion
right on the tip of his nose.
03:45
It's got those telangiectasias.
03:47
It's more of a reddish coloration.
03:49
I don't think seborrheic keratosis
is where we're going here.
03:53
Let's leave that one off the list
and move on to the next one.