So causes of delayed puberty in boys are multiple,
but generally if they are central they are more likely to be a cancer.
In boys, we're gonna suspect this
if there is no testicular enlargement after 14 years of age.
In girls, we're gonna suspect delayed puberty
if there's no thelarche by the age of 13.
So boys are allowed the next 3-year delay.
They start later, they finish later.
Keep in mind though that 2.5% of healthy boys and girls
do have delayed puberty
We're using this cut-off so that we can check kids
as early as we can without having to test too many children.
So what are the types of delayed puberty?
Well, we have constitutional delay.
This is by far the most common.
These are simply children who are having their puberty later.
Much like they might have a later growth spurt.
This is common if there is a family history of delay,
if the parents don?t have a delay on their pubertal development,
or also in children who have excessive exercise
or work very hard at the sports. Sometimes this will happen.
There may be a problem with the gonadotropin.
The gonadotropins are FSH and LH.
This would be hypogonadotrophic hypogonadism.
In other words, their gonads are less productive
because of a hypogonadotrophic state.
This is a problem with the brain
or they might have primary gonadal failure
which is hypogonadotrophic hypogonadism.
This is because they have lots of gonadotrophs and very little response.
So let?s drill down on causes of hypogonadism.
When the gonadotropins are the problem,
there are some central issues that we might see.
One classic example is Kallmann syndrome.
This is an isolated deficiency in the pituitary
and also these patients often have anosmia.
So, they are not smelling very well
because of the problem with the first cranial nerve
and they will have isolated deficiency of production of their gonadotropins.
This can be functional as well,
patients with eating disorder, excessive exercise,
some of our real-star athletes, will have a delay in their puberty
and that?s a central process.
Like we stated in boys, often it is a pituitary lesion
so we need to worry about pituitary lesions in these children.
And certainly, we would worry about it in a child
who has a history of pituitary surgery.
Remember, resection of pituitary adenomas
carries with it about a 15% chance
of being having problems with pituitary endocrine function afterwards.
Flip side, if there?s primary gonadal failure
we have to think about some other potential causes of what?s going on.
There are some genetic causes such as Klinefelter?s,
which is XXY or Turners syndrome which is just one X.
And in both those genetic situations,
children have a decreased responsiveness of their gonads
to the gonadotropin that?s trying to get them stimulated.
Also, patients may have a history of a radiation of the testis,
or chemotherapy, or rarely children can have autoimmune ovary disease
which will result in a hypogonad state
where there is hypergonadotropic levels of hormone,
FSH and LH, which are trying to stimulate a diseased ovary.
So if we have delayed puberty in a healthy child,
we're going to check LH, FSH, estradiol in girls, and testosterone in boys.
If the child has a concern, it's gonna be largely guided by our exam.
What is the problem?
Consider thyroid hormone levels, prolactin levels,
and CBC, and sed rate as a way of measuring chronic malingering condition.
Delayed puberty, if there's constitutional delay
we're gonna manage it simply by reassurance.
Eventually your child is gonna have their period,
don?t you worry about a thing.
For boys, we typically treat this with testosterone injections.
Typically, this happen about once a month. It's not too troublesome.
Families don?t usually have a problem with it
but it is expensive and so you probably will have to document
testosterone deficiency prior to the insurance company
being willing to pay for the therapy.
For girls with delay,
you can consider initiation of estrogen therapy.
Usually, we simply put them on an estrogen pill
like an oral contraceptive pill
and that will start to promote the puberty and get them regular.
So that?s all I have today about delayed puberty
and how we deal with that problem.
Thanks for your attention.