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Cyclooxygenase (COX) and Thromboxanes – NSAIDs (Nursing)

by Prof. Lawes

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    00:00 So, let's look at NSAIDs and thromboxanes together because NSAIDs, nonsteroidal anti-inflammatories, block the Cox enzymes and you end up with less thromboxane.

    00:14 So that's a lot of words on the screen.

    00:16 You might wanna put NSAIDs and thromboxanes equals less thromboxanes so, you end up with less clotting throughout your body.

    00:25 Because these thromboxanes are a member of the family of lipids known as, right, you've got the name right there. Underline that.

    00:34 Just to remind you, it's not the most important point to memorize, but remember that it's a family of lipids.

    00:40 So, I would circle family of lipids, that would help me remember what thromboxanes are.

    00:45 Now, it's usually made by platelets, it causes blood clotting, or platelet aggregation.

    00:49 Remember, when there's a platelet party, when platelets get together, that makes a block or a clot.

    00:57 So, you have platelet aggregation and constriction of blood vessels, both very helpful mechanisms if I have blood that's leaking out of my vascular system.

    01:08 Now, there's two major ones, thromboxane A2, and thromboxane B2.

    01:12 That's just an FYI. So, I would just kind of put FYI by that for you.

    01:18 That's not something that I would invest a lot of time.

    01:20 I just wanted you to know that there are actually two types that we're kind of talking about here.

    01:24 But you can always remember with this study tip, thromboxane is named because it promotes thrombosis which is forming of clots.

    01:34 So, that's just another way to remember that's what thromboxane does.

    01:37 Remember with NSAIDs, do we have more thromboxane or less thromboxane? Right. We have less. So, with NSAIDs, I'm going to bleed easier.

    01:52 Right, I'm not gonna clot as efficiently.


    About the Lecture

    The lecture Cyclooxygenase (COX) and Thromboxanes – NSAIDs (Nursing) by Prof. Lawes is from the course Central Nervous System (CNS) Medications (Nursing).


    Included Quiz Questions

    1. Aspirin
    2. Heparin
    3. Warfarin
    4. Aprotinin

    Author of lecture Cyclooxygenase (COX) and Thromboxanes – NSAIDs (Nursing)

     Prof. Lawes

    Prof. Lawes


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