Cutaneous Manifestations of HIV in Patients with Darker Skin: Introduction

00:01 Welcome to our lecture on HIV and skin conditions.

00:08 Skin disorders are common in HIV infected patients and can be the initial sign of HIV related immunosuppression.

00:17 Up to 90% of HIV infected individuals will suffer from skin diseases during the course of their illness.

00:25 Fungal and viral infections are the most common skin disorders that we see in HIV or AIDS patients.

00:36 So what causes the skin manifestations in HIV? This can be due to HIV infection itself, or opportunistic disorders secondary to the decline in Immunocompetence, and can be due to antiretroviral medications as side effects of drugs. The severity of the diseases increased with the decline in CD4 count.

01:03 Depending on the level of CD4 count, one sees various skin conditions, and if you look at this slide, you can see that with CD4 counts between 200 and 400, you see those kind of conditions.

01:17 And if it's less than 200 you will see CMV, atypical mycobacteria and deep fungal infections.

01:27 So what dermatological disorders are commonly seen in HIV patients? Firstly, infections, patients with HIV tend to have an increased susceptibility to bacterial, viral, fungal and parasitic infections.

01:44 One may also see some of these inflammatory conditions, for example psoriasis, seborrheic dermatitis, eczema, and others. Drug reactions are also very common in patients with HIV because of the multiplicity of drugs that they may be on.

02:00 Some conditions like Morbilliform eruptions, Stevens-Johnson syndrome, and toxic epidermal necrolysis, and others like fixed drug eruption.

02:11 We do see neoplasms as well in patients with HIV AIDS.

02:15 And the most typical and classical is Kaposi's sarcoma.

02:18 And of course, sometimes squamous cell carcinoma and other malignancies.