00:01
more highly than others, so we'll talk a little
bit about how those rankings occur.
00:01
So that takes us to evidence-based medicine.
Evidence-based medicine is not a new idea,
but it's taken off in recent years, it has
become very, very popular. It is the attempt
to integrate best research evidence with
clinician's personal experiences and values
of their patients to make, again, meaningful
evidence-based clinically appropriate choices
and decisions for their patients. It's a way
to use literature to help you make clinical
decisions in a systematic fashion. What does
systematic mean? Systematic means there's
a process, there's a list, there is a step-by-step
procedure to follow, by which we assess and
collect the best quality evidence and summarize
it in a way that answers the clinical question
that we are trying to ask. So again EBM is
the application of critical thinking in order
to make clinical decisions. So what's best
research evidence? We're trying to summarize
the best research evidence to allow us to
make clinical decisions, what does that mean?
It's clinically relevant research, sometimes
it comes from basic sciences, by which I mean
lab sciences, but typically it comes from
the medical literature, that is, peer-reviewed
literature written by doctors or medical scientists
to be consumed by other medical scientists
and doctors. What's clinical expertise? That's
your expertise as a clinician or a doctor
or a nurse or some other kind of caregiver.
So it's your ability to identify your patient's
unique needs and make the evidence that you
collect relevant for this particular case
that you are interested in. What's patient
values? Just because you find answer from
literature, doesn't mean it's going to correspond
to your patient's needs. For example, maybe
your patient has religious beliefs that don't
allow him or her to accept the finding that
you have found in your research, or maybe
they prefer pain alleviation or lifestyle
considerations more so than lifespan elongation.
These are things to consider when assessing
the evidence in making your final clinical
decision. But why is EBM so interesting all
of a sudden? It has been around for a long time,
it has been around since post-revolutionary
Paris, but a couple of things, well four things
in particular have caused it to gain a lot
more traction in recent years. First is that
doctors need daily information about how to
conduct their practice, diagnosis, prognosis,
therapy and prevention. That's always been
the case, but now doctors are seeing more
patients than ever before and are seeing a
wider variety of conditions than ever before,
so daily information is needed. Second, the
textbook that doctors have often relied upon,
are now out of date. Research is coming in
so fast and so furiously and so groundbreaking,
that very often the textbooks are simply not
relevant anymore. There also too many journals
to plow through, you haven't got a lot of
time to go through them all, so what do you
do? Your knowledge as a clinician is going
to decline over time, this is the nature of
the world, we're all getting older, we're
all retaining less information in our brains
and we're knowing a little bit less. We're
getting wiser, but we're knowing less. You've
got only a few seconds every day to deal with
a mountain of evidence in between patients
and you've got about 30 minutes a week that
you can set aside to do additional reading
to maintain your clinical expertise. Those
are all some serious considerations that need
a new practice, a new process, by which we
can interrogate the literature to gain clinical
expertise to answer clinical questions.
03:27
That takes us to evidence-based medicine.
It's essentially a series of strategies for
finding and appraising the best quality evidence,
it's the appraising part in which the epidemiology
really kicks in. How do we decide which evidence
is good, which is bad? Bad is not the best
word here, which evidence is good and which
evidence is perhaps not as good as others.
03:49
EBM allows us to look at systematic reviews
and look at summaries for ongoing research;
we will define what systematic reviews are
in a second, but file that term away in your
memory right now. EBM also has spurred the
development of evidence-based journals. These
journals are now allowing us to do searches
that we know are focused on good quality evidence
and not just on opinion or one-off studies
or things like that. It really shortens the
time span between having a question and finding
relevant information. We have new information
systems now. I'm talking about computers,
it will allow us to search very, very quickly.
04:27
Imagine doing the kinds of searches I'm going
to show you in a second, 20, 30 years ago
before there were computers. We had to go
to libraries and search through stacks of
books to find five or six articles, now we
can find hundreds at the touch of a key and
that's going to change everything. And lastly
we have these new attitudes, new generations
of doctors have new attitudes towards lifelong
learning that convinces them that they need
to be abreast of current information in order
to be the best possible conditions.
04:56
So here are the steps of EBM or evidence-based
medicine. First is that we need to convert
our need for information, whatever it might
be, whatever your patient demands, whatever
clinical crisis is convincing you that you
need to access literature, we need to convert
that information into a question, not just
any kind of question, but an answerable research
question, and we're going to do this in a
second, as an example. The second thing we
need to do is we are going to have to search
literature to find the best evidence to answer
that question. And again, what is the best
evidence? Best evidence depends upon the rankings
of studies, based upon the epidemiology of
those particular studies that you find. The
third step in EBM is to critically appraise
that evidence for its validity, impact and
applicability. We are going to decide if that
evidence is in fact worthy of being included
in the soup of evidence that will inform the
answer to your question. And lastly we're
going to integrate that evidence with your
particular clinical expertise. What does that
mean? It means that you have wisdom, gained
from a lifetime spent treating patients, or
observing patients or doing research that
you need to be able to bring to bear on top
of all the research that you've currently
conducted. This is because EBM is not simply
an automated mechanical computerized system
that a machine can do; it requires a human
being to apply their skill sets, plus their
wisdom, in order to make an appropriate clinical
decision. And lastly we'd like to evaluate whether
or not we’ve done a good enough job. To
be honest, very few practitioners do the evaluation
phase, but we encourage you to do so anyway.
06:38
So let’s go through those three conditions
that I mentioned just now, validity, impact,
and applicability. What does validity mean?
Validity is the closeness to the truth or
the real world that the study that you find
purports to be. Let me think of an example
for you. Let’s say you find a study that finds
an association, a connection, a relationship
between maternal diet and child’s intelligence,
and they find that mothers who eat a lot of
fat have children who grow to be very, very
intelligent, but they measure intelligence
via education level. In other words, the highest
education that that child achieves is a proxy
measurement for that child’s intelligence.
Now right away, I hope you see the problem,
just because you have a high education doesn’t
mean you are intelligent, just because you
have a low education doesn’t mean you are
not intelligent. So education is an invalid
measurement of intelligence. So that study
would fail the validity test.
07:38
A facetious example of a valid measure
is to say that a score on an IQ test
is a valid measurement of one’s ability to write IQ tests.
A less facetious example is to say
that an ultrasound scan is a very valid test for pregnancy.
07:52
Impact is important. So you may find a relationship
between two factors that's relevant for your
question, but is the impact great enough to
warrant you interest, and by impact I mean
effect size. Did the subjects in the study
change by 5%, 10%, 20%, what’s relevant
to your particular condition for your patient?
And lastly, applicability. You may have found
a very relevant study that talks about something
very similar to the question that you are
asking it, but is it applicable to your case?
Maybe the studies you found were down on young
men and your patient is an older woman, you
have to ask yourself, is that distinction?
Important for your particular circumstance.