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Characteristics of COVID-19

by Sean Elliott, MD

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    00:01 COVID-19 Viruses.

    00:04 The severe acute respiratory syndrome or SARS-Coronavirus II virus, is an encapsulated virus which measures, approximately 125 nanometers in diameter.

    00:15 It contains a single strand positive sense RNA genome, measuring 26 to 32 kilobytes, it is the largest of all RNA viruses.

    00:25 The SARS-Coronavirus II contains, four structural proteins, the first three are the “S-Protein” or “Spike” protein, “E-Protein” or “Envelope” protein and “M-Protein” or “Membrane” protein.

    00:39 Together, these three proteins constitute, the viral envelope, which is so characteristically seen, by electron microscopy.

    00:47 The lipid membrane is next in the structure of the virus and then the “N-Protein,” is the nuclear capsid protein, this encloses and provides attachment or complexing points, with the RNA strand the RNA genome, it also helps regulate the RNA synthesis.

    01:06 The S-protein or spike protein, is perhaps the most infamous or perhaps famous, in terms of the science and discovery involving the SARS-Coronavirus II virus.

    01:17 It is an appearance club shaped or even crown like, when seen from the surface on scanning electron microscopy.

    01:25 It is, of course, responsible for the binding of the virus, to its target cells via the acetylcholinesterase II receptor, on epithelial cells and including some endothelial cells, in the host cell membrane.

    01:39 It is also the target of most current vaccines against the SARS-Coronavirus II.

    01:45 The E-protein or envelope protein, is responsible of course for viral assembly and the M-protein for membrane also for viral assembly, as well as participating in release of newly formed virions or viruses, from their target cells, however, to date, the mechanism for this release, remains unclear.

    02:04 As you can imagine, there is an incredible amount of discovery ongoing, for this particular virus as it is causing the global pandemic, we know is COVID-19.

    02:14 Yet, more remains to be described as we go further into understanding, the impact and structure of this very important virus.


    About the Lecture

    The lecture Characteristics of COVID-19 by Sean Elliott, MD is from the course Coronavirus.


    Included Quiz Questions

    1. Spike (S) protein
    2. Lipid membrane
    3. Envelope (E) protein
    4. Membrane (M) protein
    5. Nucleocapsid (N) protein

    Author of lecture Characteristics of COVID-19

     Sean Elliott, MD

    Sean Elliott, MD


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