Control of Enzyme Activity

by Kevin Ahern, PhD

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    00:00 So now we have seen this epinephrine glucagon insulin pathway regulating the most important energy producing or energy storing molecules in the cell.

    00:11 This coordination of activities that you have seen is very important and let's go through that one more time.

    00:18 Insulin is stimulating the uptake of glucose; because, glucose concentration high in the blood stream is a problem.

    00:24 Epinephrine is favoring the opposite process which is the stimulation of the production of glucose from the liver; because, the body has low blood glucose levels and needs them.

    00:33 Insulin stimulates glycolysis which is the use of glucose and it stimulates glycogen synthesis which is also using that glucose.

    00:41 Thereby keeping the intracellular glucose concentration also low.

    00:47 So not only is insulin favoring the lowering of the glucose in the blood, it's favoring the use of that glucose inside of the cells so that it doesn't cause problems.

    00:57 Epinephrine glucagon, by contrast, stimulates gluconeogenesis and glycogen breakdown; because, it's favoring the release of glucose from the cell.

    01:08 Insulin stimulates the dephosphorylation of the enzyme making fatty acids, acetyl-CoA-carboxylase and therefore favors fatty acid synthesis and by extension, fat.

    01:20 Epinephrine and glucagon stimulates the activity of the enzyme that breaks down fat, triacylglycerol lipase and favors fatty acid release from fat.

    01:31 Now these many events are coordinated in this one slide here, so I am not gonna through the entire slide and talk about that.

    01:40 But so far as I say that epinephrine is favoring the breakdown of molecules to either release glucose or favor energy; because, when it favors the breakdown of fat it's favoring energy for the body which is needing energy.

    About the Lecture

    The lecture Control of Enzyme Activity by Kevin Ahern, PhD is from the course Metabolic Control.

    Included Quiz Questions

    1. Helping the adrenaline in stimulating the liver cells to release glucose-1-phosphate
    2. Lowering of blood glucose levels
    3. Stimulating glycogen synthesis
    4. Stimulating fat synthesis and storage
    5. Deactivating the enzyme triacylglycerol lipase via dephosphorylation

    Author of lecture Control of Enzyme Activity

     Kevin Ahern, PhD

    Kevin Ahern, PhD

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