00:00 Now the third one is gastric impact and I know you're gonna nail that because we've walked through that a couple times. 00:06 So write yourself some quick notes and enjoy what you've already learned before we go on. 00:16 Let's see how you did. Okay, so gastric impact of Cox-1, you're gonna have these inhibitors. 00:23 You're gonna end up with some stomach upset, intestinal bleeding, and ulcers. 00:27 Those are the big three but look, they're all attached to each other because it's coming from irritation of that lining. 00:35 Lack of protection for your stomach lining. 00:38 That's why their stomach feels kind of upset. 00:40 Now, severe would be an ulcer or at least to intestinal bleeding. 00:45 Those are a lot more intense but nobody likes an upset stomach. 00:49 Again, all three line up with -- hey, with Cox-1 inhibitors, I'm gonna have less of this available so that's why you're gonna have these three effects. 01:00 The stomach upset, a risk for bleeding, and ulcers. 01:04 So how do you minimize that because nobody wants to experience those or have an upset stomach? Well, sometimes taking your NSAIDs with a full meal, that will also help you. 01:16 Now I know we say up there with an antacid. 01:18 You have to be really careful with that and you wanna talk to your health care provider before you would use that strategy. Why? An antacid is over-the-counter. 01:28 Yeah, it is but an antacid will change the pH of your stomach, the gastric pH of your stomach, so that will also impact the absorption of the NSAID. 01:40 So you wanna be very clear, have a conversation with your health care provider and say, "Hey, I'm having some gastric upset." Now, you can take an NSAID with a full meal all on your own but before I would take any oral medication with an antacid, I would wanna talk with my health care provider and talk about what impact will this actually have on this particular NSAID. 02:02 Because usually, it makes them -- when you mess with the pH, it makes a drug a little bit less effective. 02:07 Now that's -- if that's helpful to you like you're weighing out the risks and the benefits with your health care provider, you can come up with the best solution for you. 02:16 Not for your neighbor, not for a friend, but the best care solution for you. 02:21 So that advice that the health care provider gives is simply for that patient in that setting. 02:28 Now, we've got some fancier things, right? We're just talking about antacids and food. 02:33 That's something that everybody has access to but there's also the drugs that you'll see on your screen there. 02:38 Misoprostol, that's cytotec. That can be used to help reduce stomach irritation with NSAIDs. 02:44 Now prilosec, these are gonna start to look familiar. Omeprazole, you've got Nexium. 02:50 These are gonna look like proton pump inhibitors, right? Those can help with dealing with less gastric acid. 02:57 Your stomach's upset because their lining isn't as protected as it used to be so one strategy is to use these drugs that we're talking about. 03:06 After the cytotec, we're using these drugs to directly minimize the gastric acid so that's how they can help deal with a gastric upset that comes with NSAIDs. 03:16 They're proton pump inhibitors. Now that is a powerful group of medication. 03:23 You see we've got them linked besides the misoprostol. 03:26 Proton pump inhibitors are the drugs that are the most effective at minimizing gastric acid. 03:33 So they're better than the H2 blockers. They're just the most effective group of drugs. 03:38 They're meant to be used for a short period of time so you'll -- that's another drug you'll in consultation with your health care provider. 03:46 Even though different dosages of these -- some of these drugs are available over the counter, you wanna make sure that the health care provider is aware of what you're taking.
The lecture Contraindications: Gastric Upset – NSAIDs (Nursing) by Prof. Lawes is from the course Central Nervous System (CNS) Medications (Nursing).
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