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Combination of Cardiac and Vascular Function Curves – Regulation of Venous Pressure

by Thad Wilson, PhD
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    Now we're going to do some combinations, some integration of some of the aspects we've already discussed. Adding to it, vascular function curves. So cardiac function curves are oftentimes dealt with to things like the Frank-Starling mechanism where you usually plot either central venous pressure or left ventricular and diastolic pressure on the X axis then you plot cardiac output or something like stroke volume on the Y. Here, to make sure that the link happens with vascular function curves, we're going to use central venous pressure plotted against cardiac output. Here we have our traditional vascular function curve flipped a little bit on its head so that we have cardiac output now on the Y axis, rather in vascular function curves we usually put it on the X. So let's trace through this kind of curve. The normal operating point. You usually have a cardiac output of around 5 liters. The central venous pressure that corresponds to 5 liters is about 2 mmHg. Remember that central venous pressure is most of the time between 0 and 4 mmHg. The intersection point here is the most important thing. We're going to call this part here this equilibrium point. Wherever the equilibrium point is is what the body is going to try to adjust. So, let's go through a number of clinical scenarios that might affect either the heart or the vasculature and let's see how the body would want to respond to that with a change in this equilibrium point. Starting with normal, our first condition is a decrease in contractility or inotropy. So this could happen very clinically by something like a heart attack. Someone had a myocardial infarction or a heart attack which decrease their heart's ability to pump, it decreased their inotropy contractility. Now instead of...

    About the Lecture

    The lecture Combination of Cardiac and Vascular Function Curves – Regulation of Venous Pressure by Thad Wilson, PhD is from the course Vascular Physiology.


    Included Quiz Questions

    1. 5 liter/min
    2. 1 liter/min
    3. 2 liter/min
    4. 3 liter/min
    5. 4 liter/min
    1. Increase volume
    2. Increase force of contraction
    3. Increased heart rate
    4. Increased conduction
    5. Decrease volume
    1. Decrease central venous pressure
    2. Decrease ionotropy
    3. Decrease conduction
    4. Decrease heart rate
    5. Vasodilatation of vessels

    Author of lecture Combination of Cardiac and Vascular Function Curves – Regulation of Venous Pressure

     Thad Wilson, PhD

    Thad Wilson, PhD


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