00:00
So the clinical manifestations of tuberculosis
are lung alone, pulmonary, which is nearly
half the people. A combination of lung plus
outside of the lung disease, which is only
about 10% of people, and then there's just
extra pulmonary disease, disease that is not
affecting the lungs, includes the mediastinal
lymph nodes, because they are not actually
part of the lung, they are in the mediastinum.
It also includes pleural tuberculosis, because
pleura, the infection is actually of the pleura
itself, again that’s not the lung parenchyma.
00:32
Now an important distinction here is that
the infective disease of those patients with
pulmonary disease and all the extra pulmonary
forms of tuberculosis are essentially not
infective. You can see there is quite a big
list of different sites that can be affected
by extra pulmonary disease and the frequency
is given here as well.
00:50
The commonest being nodes, lymph nodes, mediastinal
lymph nodes, being the commonest sites.
00:56
But It could be pleural, you can have bone and
spine disease, you can have miliary tuberculosis
which is a very specific form where the tibia
has been spread by the blood throughout the
body, affecting mainly the lungs, the liver
and the bone marrow. Meningitis, which a very
serious form but relatively rare fortunately,
and then the various parts of the abdomen
can be affected as well. So the classic symptoms
of someone presenting with pulmonary tuberculosis
is very simple, they cough and they may cough
with blood present in the sputum, haemoptysis,
and with that they’ll have systemic symptoms
because it is an active infection and these systemic
symptoms are prolonged because the patient
presents with several weeks even months’
worth of history. So over that time the patient
is feeling ill, they are not eating, and they
have fevers and night sweats, and they’ll
be losing weight as well. And that's very
important for identifying somebody who may
have active tuberculosis, the presence of
the systemic symptoms. Now the other areas
within the thoracic cavity that may be affected
are the mediastinal nodes as we've mentioned,
but really that doesn't normally cause symptoms
of the nodes themselves and is visible on
the chest X ray and that sort of patient will
present a systemic symptoms but no, necessarily
respiratory symptoms. And pleural disease
that causes an exudative pleural effusion,
and that presents largely with breathlessness
and the systemic symptoms that we've described
already.
02:20
Now if you have extra pulmonary disease, how
you present depends on the site of disease,
clearly. So cervical lymph node involvement
is very common and those patients will present
with a lump palpable in the neck, that they
can feel or see themselves. That lump tends
to be smooth, its firm and its not particularly
hard. If they have mediastinal abdomen lymphadenopathy
then that will be identified by X rays. Gastrointestinal
disease will cause pain, bloating and ascites.
02:50
Pericardial disease causes a constrictive
pericarditis, pericardial effusions.Meningitis
presents with chronic headaches, focal neurology
and eventually coma, it is a very serious problem
with a high mortality and even if you do survive
it, you are likely to have a neurological
defects as well. Miliary TB I've mentioned
is where you have bloodbornes spread across
the body and actually that’s very difficult
to diagnose because the patient have very
few in the way the localizing the symptoms,
they just have the systemic symptoms in weight
loss, but the chest X ray is often characteristic
showing very small nodules throughout both
lungs. If you have bone or joint TB that will
be presented with a mass and pain of that
bone or joint that’s being affected. And
if you have nodal TB and bone and joint TB
then what can happen is that the infection
can penetrate through the skin and cause what
we call the discharging sinus, where you have
a hole going into the infected area that oozes
out fluid, and tuberculosis always can be
seen in that fluid. So just to give you a
couple of case histories, to give a feel for
what this disease and how this disease presents.
03:58
This first patient is a man from India, he
has had three months history of systemic symptoms
of weight loss, night sweats, and feeling
not very well. And with that he's had a cough
and if you can see the chest X ray what you
can see is bilateral apical disease here,
and there is cavitation present and this is
a very classical presentation for someone
with pulmonary tuberculosis. Systemic symptoms,
cough and a chest X ray showing upper lobes
changes with cavitation, and given the man
was born in India, this is almost certainly
going to be tuberculosis because he is from
a higher risk group with a real classical
presentation of pulmonary tuberculosis looks
like and his sputum should show acid fast
bacili because this is a high bacillary load,
high bacterial load disease. This is a different
presentation. This is a Somalian, has moved
to London and now he is presenting with two
months history of back pain and again systemic
symptoms of sweat, feeling not very well and
a bit of weight loss. Now the back pain is
the localizing symptom for where the problem
is and you see this on this MRI scan, there's
an area of high density,
and in fact if you look closely there is destruction
of the edges of those vertebra and there is
some soft tissue swelling around those bones
and you can also see that there is an angulation
occurring there. And this is spinal TB, and
the MRI appearance there are very classical
for tuberculosis. So again we have somebody
from a high risk area, sub-Saharan Africa,
so therefore has been exposed to tuberculosis
as a child quite likely to have been. Recent
emigration, which is a risk factor, systemic
symptoms which are very indicative of active
inflammatory or infective disease, tuberculosis
being one of the common causes and a characteristic
radiology. So, just to re-iterate that, to
recognize tuberculosis, really you need two
things, systemic symptoms plus a high risk
group. So somebody's got weight loss, fatigue,
fever, sweats who has been born in a high
risk country, sub-Saharan Africa, Asia, or
is homeless, intravenous drug abuser, alcoholic,
has been in a prison, or is HIV positive.
With that combination you must think about tuberculosis.
06:14
And the localizing symptoms will help as well,
because if somebody has classic localizing
symptoms, that will also make the disease
much more likely.
06:25
A family history of exposure to tuberculosis
is sort of helpful. If somebody says “yes
my aunt had TB when I was a child” then that
means they are quite likely to have latent
tuberculosis but we don’t often get that
history.