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Group 5: Other Antiarrhythmics – Antiarrhythmic Drugs

by Pravin Shukle, MD
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    Let's talk about the group 5 drugs. Let's start with adenosine. So adenosine is actually an endogeneous compound. We actually have adenosine in our bodies. Now adenosine acts on the purine receptor. It completely blocks conduction in the AV node. It causes quite significant membrane hyperpolarization and it increases the potassium current. It is a very short duration of time. Now, when I say short duration I mean short duration. We think that it lasts in the blood for maybe 6 or 7 seconds because it's not broken down in the liver and it's not broken down in the kidney, it's actually broken down by red blood cells. Now one of the major side effects of using adenosine is chest pain. When we are talking about adenosine, I do want to mention one thing. How you give this drug is really important. And as you go on to your clerkship and work on code teams you have to know that adenosine has to be given IV push with a follow up. So you take your adenosine syringe, you get it ready. When you are told to give it you give it and you push it hard as you can into the IV line. Then you take a saline flush and you flush it after that. You need to get that drug into the heart as quickly as possible because it has such a short duration of action. The other thing I am going to warn you about is that the patients will complain of chest pain like you've never seen. So the first time I ever gave adenosine as a medical student. I push this adenosine, the patient had a supraventricular tachycardia with a heart rate of around 175 and the monitor went flat for about 6 seconds. And I...

    About the Lecture

    The lecture Group 5: Other Antiarrhythmics – Antiarrhythmic Drugs by Pravin Shukle, MD is from the course Cardiovascular Pharmacology.


    Included Quiz Questions

    1. ...acts on the purine receptor to directly simulate the pain of cardiac ischemia, and will block AV nodal transmission.
    2. ...is a medium potency drug that will last up to one minute.
    3. ...is a low potency drug that will last up to one hour.
    4. ...is a potent calcium channel blocker that will completely block the AV node.
    1. ...is a divalent cation that directly depresses ectopic pacemakers.
    2. ...is a monovalent cation that directly depresses ectopic pacemakers.
    3. ...is a divalent cation that directly depresses the pacemaker (SA Node).
    4. ...is a monovalent cation that directly the pacemaker (SA Node).
    1. ...is a particularly dangerous type of ventricular tachycardia that responds to magnesium.
    2. ...responds well to class IA anti arrhythmic drugs.
    3. ...is best treated with the divalent cation calcium.
    4. ...is a particularly dangerous type of ventricular tachycardia that responds to calcium.
    1. ...stop the nurse from defibrillating the patient. You tell everyone to wait.
    2. ...prep for defibrillation. Administer atropine IV push.
    3. ...change your underwear. Apply for trucking schools and give up on your dreams to be a doctor.
    4. ...stop the nurse from defibrillating the patient. Administer cardiopulmonary resuscitation.

    Author of lecture Group 5: Other Antiarrhythmics – Antiarrhythmic Drugs

     Pravin Shukle, MD

    Pravin Shukle, MD


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    Super on point and hilarious! XD
    By Juan Carlos R. on 01. June 2017 for Group 5: Other Antiarrhythmics – Antiarrhythmic Drugs

    LOL That adenosine mental image will NEVER leave me ajajajajajaja