00:00
So how do patients with
COPD present its breathlessness on exertion,
and the level of exertion necessary to make
them breathless would tell you how severe
the disease is. So for example, you have a
patient that says I can walk on the flat for
miles and miles, but if I try and walk up
a steep hill, I find it very difficult and
gasp and have to stop half way up. I suggest
they have relatively mild disease that allows
them to do most everyday life things, but
only detectable to them when they do severe
exertion. However, the more severe patient
will say, “I will get breathless when I
will walk a hundred yards”, and many of
the patients which I see in my clinic are
not able to walk more than 50, 60, 70 yards,
before they have to stop to catch their breath,
and some will be breathless walking between
the bedroom and the bathroom. This degree of
dyspnoea is a chronic background situation
where there are fluctuations and this actually
happens on a day to day basis. It's not clear
why, it has probably to do with the weather and pollution
levels, but patients will have a bad day and
then followed by a good few days. As well as
breathlessness, the other common
symptom is a cough and that is usually productive
of dirty looking, grey black phlegm, it could
be white as well. That's the chronic bronchitis,
and that reflects the increase in the mucous
glands and the hyperplasia of those glands producing
more mucous due to the cigarette smoke induced
inflammation. And chronic bronchitis is defined
as 'daily cough with sputum production
that lasts for at least 3 months and for two
years in a row'. Other symptoms that patients
get, they can get a wheezy chest, they occasionally
cough up a little bit of blood. They get various
aches and pains in their chest because of
the coughing and the breathlessness pulling
on the muscles and the ribs during respiration.
With bad disease, developing cor pulmonale
to chronic hypoxia, they'll have ankle oedema.
And patients with chronic hypoxia and severe
airways obstruction will feel tired, they'll
lose energy, and some patients actually do
have gradual weight loss, and can get to the
level of having cachexia. If they develop
type 2 respiratory failure or a rise in PCO2,
that's associated with morning headaches and
drowsiness. An important thing about COPD
is that many patients, not all, also have
acute deteriorations. And these are sustained
increases in severity of the illness, and
they last a few days to a few weeks. They
are usually precipitated by a viral infection
but they can occur for other reasons, which are
not clear. Some patients don't get exacerbations,
they are non-exacerbators, they have chronic
breathlessness, but they don't change with
their degree of the breathlessness. Other
patients exacerbate infrequently once every
year or two, once every few months, and there
are other patients who exacerbate very frequently,
as often as very few weeks. And these exacerbations are
quite often severe enough to require hospitalization.
03:09
As I said, they are frequently precipitated
by a viral or bacterial infection, but not
always. So how do you recognize the exacerbation?
Well the patient may have viral upper respiratory
tract infection, symptoms of sore throat, a
bit of a runny nose, and then develop a bit
of a cough. And with that cough, they start
to produce more phlegm and becomes a bacterial
infection, the phlegm will go green and thick
and that’s a marker of active bacterial
infection of the bronchiole. And as that happens,
the patient gets increasing dyspnoea, their
normal exercise tolerance falls, they are
less able to do what they should be able to
do normally, and the cough will increase,
and there may be a fall in their lung function
markers that keep flow in the FEV1, but not
always. Patients with severe COPD, their FEV1
will be about 0, 0.8 and an exacerbation may
not change that much at all.