Choroid Plexus and Cerebrospinal Fluid (CSF)

by Craig Canby, PhD

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    The cerebrospinal fluid is produced by specialized structures. These structures are referred to as the choroid plexuses. So it’s important for you to understand their unique features as well as their particular function. So the features and function of the choroid plexus would be they’re located in all of the brain ventricles. So we see a choroid plexus in the lateral ventricle here. It would be found in the contralateral, lateral ventricle. It would also be found in the third ventricle. In this area here, we have the diencephalon and then in the fourth ventricle as well. These specialized structures have a villous appearance to them. These villi or projections contain blood vessels. There is a special choroid epithelium associated with the choroid plexus. So here, we can see an illustration of the choroid plexus. So this is a villus, an expansion or an extension of epithelial cells. You can see in the core of this villus, you have a blood vessel, lumen of the blood vessel, endothelial cells then they have special choroid epithelium and these are ependymal cells. You can see the apical specializations of those ependymal cells which constitute the choroid epithelium. This arrangement allows for the development of a barrier between the blood and the cerebrospinal fluid. Functionally, this is the structure that’s responsible for the production of cerebrospinal fluid. So there would be movement of fluid from the blood through the endothelium, through the ependymal cells into the ventricular cavity. The volume and pressure of cerebrospinal fluid is that in the ventricular system of the brain and as well as the subarachnoid space and central canal of the spinal cord, there’s approximately 150 milliliters of cerebrospinal fluid. There is variability from one person to another but this is a nice round, average type of volume....

    About the Lecture

    The lecture Choroid Plexus and Cerebrospinal Fluid (CSF) by Craig Canby, PhD is from the course Ventricular System.

    Included Quiz Questions

    1. Reabsorb CSF
    2. Located in all ventricles
    3. Villous appearance
    4. Choroid epithelium
    5. Contain blood vessels
    1. Ventricles-->Central canal of spinal cord-->Subarachnoid space-->Absorption into arachnoid granulations
    2. Ventricles--> Subarachnoid space --> Central canal of spinal cord -->Absorption into arachnoid granulations
    3. Ventricles-->Central canal of spinal cord-->Subdural space-->Absorption into arachnoid granulations
    4. Subarachnoid space -->Central canal of spinal cord-->Ventricles -->Absorption into arachnoid granulations
    5. Ventricles-->Central canal of spinal cord-->Subarachnoid space-->Absorption into Choroid plexus
    1. Contrecoup injury
    2. Transtentorial herniation
    3. Cephalohematoma
    4. Caput succedaneum
    5. Respiratory depression
    1. Rate of absorption is same as the rate of production
    2. It is produced by arachnoid granulations and absorbed by choroid plexus.
    3. Hypothalamus is the main source of CSF.
    4. An increased CSF pressure could result in brain atrophy.
    5. A decreased CSF pressure could result in brain herniation.

    Author of lecture Choroid Plexus and Cerebrospinal Fluid (CSF)

     Craig Canby, PhD

    Craig Canby, PhD

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