Changes in Body Fluid Compartment

by Thad Wilson, PhD

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    Now that we have the ability to do a lot of the measurements, let's go through some body fluid compartment changes. These body fluid compartments can be broken up in a very simplistic manner into 2 boxes. We are going to use the ECF as the extracellular fluid compartment and that's about 14 liters for a 70-kg male. The intracellular fluid compartment is a larger box. It has about 28 liters if we think about this from the 70-kg male. Osmolality will go from 0 to 285, and 285 is the osmolality of blood, typically. So having this box in place, let's go through a number of clinical examples of various changes in body water. We are going to call a contraction a decrease in body water and an expansion as an increase in total body water. So our first one is a hypo-osmotic volume expansion. So let's walk through what this means. Volume expansion means that you're going to increase the volume, which means the X axis [denotions] will be larger. If it is hypo-osmotic, you will now move osmolality down. This particular case of a hypo-osmotic volume expansion can be done by drinking excess water. It will normally not change arterial pressure too much because the body is very good about getting rid of it. But if you are able to measure blood pressure, very transiently you would see a very small increase. And then we go back to normal. Sodium levels would go down. And the reason why sodium levels go down is because we're measuring it as a concentration. So simply you're diluting the sodium that you do have. So you haven't lost any sodium, but now you have more volume that you are dissolving it in. Total protein levels also go down for the same...

    About the Lecture

    The lecture Changes in Body Fluid Compartment by Thad Wilson, PhD is from the course Renal Physiology.

    Included Quiz Questions

    1. Total protein
    2. Arterial blood pressure
    3. Serum sodium
    4. Serum chloride
    1. Serum sodium
    2. Arterial blood pressure
    3. Hematocrit
    4. Cell volume
    1. Iso-osmotic volume contraction
    2. Hypo-osmotic volume expansion
    3. Hypo-osmotic volume contraction
    4. Iso-osmotic volume expansion
    5. Hyper-osmotic volume expansion
    1. Hyper-osmotic volume expansion
    2. Hyper-osmotic volume contraction
    3. Iso-osmotic volume expansion
    4. Hypo-osmotic volume expansion
    5. Hypo-osmotic volume contraction
    1. RBCs shrink but ECF is decreased
    2. RBCs are swelled
    3. RBCs remain the same
    4. RBCs shrink but ECF remains the same
    5. RBCs swell and Blood pressure increases
    1. Hypo-osmotic volume expansion
    2. Iso-osmotic volume expansion
    3. Iso-osmotic volume contraction
    4. Hyper-osmotic volume expansion
    5. Hyper-osmotic volume contraction

    Author of lecture Changes in Body Fluid Compartment

     Thad Wilson, PhD

    Thad Wilson, PhD

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    Very mixed reveiw.
    By Jermey B. on 03. June 2017 for Changes in Body Fluid Compartment

    Did good job explaining some of the expected changes, but a poor job at others and simply stated direction of arrow without explanation. Overall, a good lecture but definitely room for more detail to be discussed. Also, very surprised effects of acute blood loss/trauma was not covered.

    Absolutely fantastic
    By Asiya H. on 05. March 2017 for Changes in Body Fluid Compartment

    Absolutely fantastic. Very well explained. I retained everything from this lecture.