Cervical Cancer: Risk Factors

by Carlo Raj, MD

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    Let’s talk about cervical cancer and, in verbiage highlight the things we’ve noted. E6 and E7. E6 knocks out p53. E7 will knock out Rb. If you have a -- Now, understand the language. If you know your basic neoplasia, then you understand that if you have a hypophosphorylated Rb, that’s a key importance, if you have a hypophosphorylated Rb. This means that an Rb has not been phosphorylated. This means that the Rb is now complexed with E2F. And therefore, where is my cell? The cell is stuck between G1/S phase. However, if you have E7, the E7 is going to then remove the break. So it promotes proteolysis of hypophosphorylated Rb. Guess what E7 did. It got rid of Rb. It removed the break. If you remove the break, then E2F allows for a cell to go from G1 to S phase. Understand the normal first that I just explained. And then what happens here with high grade HPV that possess E6, E7? An issue results in cervical intraepithelial neoplasia. In case you missed what CIN stands for, there it is. C – cervical, I – intraepithelial, N – neoplasia. Is this cancer? No. Is this dysplasia? Yes. So CIN, precancerous lesion detected by Pap smear. Next, the Pap smear has been done, and screening. How important has this been for the United States or in the world in general? Really important, right? So therefore, because of the introduction of Pap smear as a screening method, and also vaccination, cervical cancer in developed countries starts dropping in terms of death by gynecologic cancers. Worldwide though, cervical cancer is still very, very common. The picture, histologically that you’re seeing here, would be an abnormal, abnormal Pap smear, in which you would then expect to find your HPV infected cells...

    About the Lecture

    The lecture Cervical Cancer: Risk Factors by Carlo Raj, MD is from the course Disorders of Vulva, Vagina and Cervix.

    Included Quiz Questions

    1. ...E6 and E7.
    2. ...E4 and E6.
    3. ...E7 and E9.
    4. ...E16 and E18.
    5. ...E5 and E6.
    1. Basement membrane of the epithelium
    2. Endothelium of the closest blood vessel
    3. Fascia between epithelium and muscle layer
    4. Squamo-columnar junction
    5. Peritoneum
    1. Regular pap smears
    2. Screening for serum Anti HPV antibodies
    3. Mandatory education about contraceptive use
    4. Annual screening for STDs
    5. Routine childhood vaccinations
    1. Cervical carcinoma invading the urinary bladder and causing obstruction to the outflow of urine
    2. Renal cell carcinoma seeding the peritoneal cavity
    3. Vasculitis
    4. A sexually transmitted infection causing UTI and PID simultaneously
    5. There is no possible correlation between the two presentations.

    Author of lecture Cervical Cancer: Risk Factors

     Carlo Raj, MD

    Carlo Raj, MD

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