Cell Cycle: Cyclin D – Carcinogenesis

by Carlo Raj, MD

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    We will pay special focus on cyclin D. First and foremost in this picture I want you to come down to the bottom and where is this RB phosphorhylation, And focus upon the RB and E2F complex. It is important that you memorise E2F and RB as being together. That complex, as long as it exists, will then properly regulate the cell as it moves from G1 to S phase. Your first arrest point that you will be focusing upon will be between G1 and S. You know everything about that arrest point first. And association with it's functioning, and regulators then you move on to second arrest point which will be in between S and G2. Now with this E2F/RB complex being present, then the cell is not permitted to move from G1 to S phase. Is that understood? How do you remove and how do you free up the E2F so that the cell can then move from G1 to S phase. The term is phosphorhylation. Whenever RB gets phosphorhylated, you remove the brakes. RB. You remove the brake. How? By phosphorhylating. In biochemistry, what's the name of that enzyme that is responsible for phosphoshylation? Kinase. Good. Would you take a look at our topic. Cyclin-D, CD what? 'K4'. What's the 'K' stand for? Kinase. What does it do? Phosphorhylate the RB. By doing so, what have you done? Remove the break. Who is set free? E2F. Who is truly set free? The cell can now move from G1 to S. Therefore, what this cancer want to do with RB? Does it want to phosphorhylate it? Or does it want to de-phosphorhylate it? It wants to phosphorhylate it so that you can remove the brake. So that the cell remains within the cell cycle eternally. What is the...

    About the Lecture

    The lecture Cell Cycle: Cyclin D – Carcinogenesis by Carlo Raj, MD is from the course Cellular Pathology: Basic Principles.

    Included Quiz Questions

    1. ERB-1
    2. E2F
    3. Rb
    4. CDK4
    5. Cyclin D
    1. Compaction of chromatin
    2. Increased transcription
    3. Rapid movement from G1 to S phase
    4. Upregulation of E2F/DP1/RB complex
    5. Decreased phosphorylation of E2F
    1. p21
    2. MDM2
    3. CDK4
    4. p16
    5. p14
    1. Increased phosphorylation of Rb
    2. Inhibition of Cyclin D/CDK4 complex
    3. Increased p53 activity
    4. Upregulation of E2F
    5. Decreased free E2F
    1. Decreased available CDK2
    2. Decreased transcription of Cyclin E
    3. Decreased transcription of Cyclin A
    4. Increased dephosphoylated Rb
    5. Increased E2F/DP1/Rb complex
    1. p27
    2. p53
    3. p14
    4. p16
    5. MDM2

    Author of lecture Cell Cycle: Cyclin D – Carcinogenesis

     Carlo Raj, MD

    Carlo Raj, MD

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