Lectures

Cell Adhesion Molecules (CAMs) – Lymphocyte Recirculation and Homing

by Peter Delves, PhD
(1)

Questions about the lecture
My Notes
  • Required.
Save Cancel
    Learning Material 2
    • PDF
      Slides Lymphocyte Recirculation and Homing.pdf
    • PDF
      Download Lecture Overview
    Report mistake
    Transcript
    What are cell adhesion molecules? Well they have adhesion molecules that are present on the surface of cells that recognize other molecules in the body. And sometimes these cell adhesion molecules or CAMs as we often call them, will promote cell-cell and cell-extracellular matrix interactions. So it may be that the molecule they recognize is on the surface of another cell or it may be that the molecule they recognize is part of the extracellular matrix. They can be expressed constitutively, in other words they’re already there, or they can be induced by pathogens and host products during inflammation. So following encounter with a pathogen or some host substance, you might induce expression of the gene for an adhesion molecule. And an adhesion molecule that wasn’t there previously now becomes expressed on the cell surface. Sometimes adhesion molecules recognize the same adhesion molecule on another cell, in other words homophilic interactions. But alternatively, an adhesion molecule may recognize a different adhesion molecule on another cell, heterophilic interaction. There are five main groups of cell adhesion molecules: The cadherins, the immunoglobulin-superfamily cell adhesion molecules, mucin-like cell adhesion molecules, group of adhesion molecules called selectins and another quite large family called the integrins. Integrins are interesting because they can signal in two different ways. They are often present on the membrane of the cell in a particular conformation, or the way that they’re folded, which means that they are a very low affinity for the ligands that they recognize and therefore are essentially inactive. However, signaling from within the cell involving the molecule talin interacting with the actin network within the cell, can lead to what is called inside-out signaling. So the signal here is being initiated from within the cell. And that signal, being delivered through talin allows a change in...

    About the Lecture

    The lecture Cell Adhesion Molecules (CAMs) – Lymphocyte Recirculation and Homing by Peter Delves, PhD is from the course Adaptive Immune System.


    Included Quiz Questions

    1. Talin
    2. Src
    3. FAK
    4. iNOS
    5. MyD88
    1. IgM-superfamily
    2. Cadherins
    3. Integrins
    4. Mucin-like
    5. Selectins
    1. Internal signaling of apoptosis
    2. Change in cell polarity
    3. Migration
    4. Changes in cytoskeleton
    5. Changes in gene expression

    Author of lecture Cell Adhesion Molecules (CAMs) – Lymphocyte Recirculation and Homing

     Peter Delves, PhD

    Peter Delves, PhD


    Customer reviews

    (1)
    3,0 of 5 stars
    5 Stars
    0
    4 Stars
    0
    3 Stars
    1
    2 Stars
    0
    1  Star
    0
     
    Too much details!
    By Jake Bryan C. on 17. January 2017 for Cell Adhesion Molecules (CAMs) – Lymphocyte Recirculation and Homing

    Great content but overwhelming. Too much details on the receptors and molecules got me lost in understanding the overall immune response. I appreciate the enthusiasm in detailing everything but the USMLE is devised to evaluate generalists and not immunologists.