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Causes of Bone Marrow Failure (BMF)

by Carlo Raj, MD

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    00:01 what other causes of bone marrow failure? What if you had renal failure? And if there is renal failure, then you are not able to produce what? Take a look, erythropoietin.

    00:09 And if there is no erythropoietin, then the bone marrow is not able to function.

    00:13 This is still under your non-hemolytic type of anemia.

    00:18 What’s myelophthisic mean? Well, you have leukemia or, in general, let’s say your patient unfortunately, she has breast cancer.

    00:25 And this breast cancer, let’s say something like invasive lobular breast cancer and it now wants to do what? Unfortunately might metastasize and it might then metastasize into the bone marrow. 14 00:00:38,760 --> 00:00:38,611 Uh-oh.

    00:40 If you go there, guess what? It completely destroys the architecture of your bone marrow.

    00:43 The cells get destroyed.

    00:45 So what kind of anemia would this be please? Our topic, it will be your non-hemolytic anemia.

    00:51 This is known as myelophthisic in general.

    00:52 Myelophthisic means is bone marrow replacement by space occupying lesion such as mets, metastasis.

    01:01 Or we’ll talk later about a condition called myelofibrosis.

    01:07 And myelofibrosis would mean that there is increased fibrosis of bone marrow, shutting it down.

    01:11 Once again, we have a type of non-hemolytic anemia.

    01:16 Now, there will be a bunch of terms that you have to be familiar with.

    01:20 To begin with the prefix myelo, myelo, myelo.

    01:22 Myelophthisic, myelofibrosis, at some point we’ll take a look at, myelodysplastic syndrome and the category of disease known as myeloproliferative.

    01:32 Now if it is myelophthisic shall we say breast cancer, take a look at what you have here in your bone marrow and you’ll notice that there is barely any space and you find these nodules that are in here.

    01:43 And well, you can’t produce anything.

    01:48 Meaning to say, the bone marrow has been shut down.

    01:49 Welcome to our non-hemolytic type of anemia.

    01:53 This will be one in which breast cancer has metastasized to your bone marrow.


    About the Lecture

    The lecture Causes of Bone Marrow Failure (BMF) by Carlo Raj, MD is from the course Normocytic Anemia – Red Blood Cell Pathology (RBC).


    Included Quiz Questions

    1. Space-occupying lesions
    2. Fat vacuoles
    3. None of these
    4. Myocytes
    5. Endotoxins

    Author of lecture Causes of Bone Marrow Failure (BMF)

     Carlo Raj, MD

    Carlo Raj, MD


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