Welcome to Pharmacology by Lecturio.
Today, we're gonna be covering the management of angina.
Now, when we take a look at these different types of drugs,
really, what we're doing is we're either increasing blood flow to the affected area
and therefore, more oxygen for the affected area.
Or B, we're reducing the oxygen demand of the affected area.
The first category of drugs that we're talking about today
are the calcium channel blockers which actually do both.
Within the drug class itself, there's different agents
and they will act more as a vasodilator and some will act more as a cardiac depressant.
The first sub-category of the calcium channel blockers are the dihydropyridine, calcium channel blockers.
These include drugs like amlodipidine, or felodipine, or nifedipine, which is the prototypical drug.
You don't need to know all of the names, just know, you know,
I think nifedipine is probably reasonable.
This is usually used as a blood pressure drug so 90% of the time that's why it's being given.
But it can be used quite effectively in angina management.
It may cause a reflex tachycardia so that can cause an increase in oxygen demand.
So obviously a drug like nifedipine is predominantly a vasodilator not necessarily a cardiac depressant.
It may worsen proteinuria in some patients with underlying nephropathy
so it's important for us to know that clearly.
The next category are the nondihydropyridine calcium channel blockers.
These are divided into two different categories
which you probably don't need to know but for completeness' sake, I put them here.
Now, the first one that I wanna talk about is verapamil.
Verapamil is sold under very many different names so, I'm just gonna use the generic term.
It reduces inotropy and chronotropy, so you can see that
unlike say nifedipine which is predominantly a vasodilator,
this one is a predominantly a cardiac depressant.
It reduces the strength of contraction and it reduces the speed of conduction down certain tissues.
So, what happens is the oxygen demand actually goes down.
It reduces coronary vasospasm and therefore may help in ischemia.
The patient is treated for arrythmia with this particular agent
but it is also a really good treatment for patients who have angina.
Other categories of drugs within this subclass is diltiazem.
Now, diltiazem kind of shares features of both verapamil and nifedipine.
It's sort of the halfway drug.
So, it does act as a cardiac depressant, it does reduce heart rate, for sure.
But it also is a vasodilator.
So, the nice thing about using diltiazem is that you sometimes get the benefits of both.
The next category of drugs that I wanna talk about are still calcium channel blockers.
I've put them in here for completeness' sake
but I just want to point out that this particular gabapentinoid class of drug
is not necessarily used for angina.
But because of the way that it works, it's important for us to know how it works.
I've thrown it in here for your for your education.
These gabapentinoids will block the alpha 2 delta sub-unit
containing voltage-gated calcium channels.
This is used in the treatment of neuropathic pain and epilepsy;
it's not used in the treatment of angina but the mechanism of action is identical
to the other calcium channel blockers, so that's why I wanted to put it in here.
I also talk about this drug in greater detail in our seizure lectures and in our pain lectures.
Another drug class is ethanol. Ethanol will actually block the L-type calcium channel as well
and it causes urinary bladder relaxation.
Now, why do I throw this in the angina lecture?
The reason why I've put it here is just to emphasize the fact that technically these drugs,
the gabapentinoids and ethanol, fall into the same category as the other calcium channel blockers
because of the way that they work on the calcium channels
and the effect that they have on certain types of smooth muscles and neurological function.
These are not being used for the treatment of angina
so I just wanna be clear about that and be very, very upfront about it.
So, it's really for a mechanistic reason that I'm putting them in here.
Now, this painting by the way is by Michelangelo,
it's Drunken Noah, it's one of the most beautiful paintings ever created
and I highly recommend that you check it out if this painting is being brought to your city.
Now, let's get back to talking about all of the calcium channel blockers as a group.
The side effects of calcium channel blockers include constipation;
you can get pretibial edema, you can get nausea; sometimes,
you can get facial flushing so the vasodilation of the capillaries in the face;
you can get dizziness sometimes and that dizziness
is more often due to low blood pressure than any kind of a direct effect.
In terms of the dihydropyridines, like nifedipine and amlodipine,
the side effects can include increased proteinuria, a reflex tachycardia,
increased ischemia so it's a paradoxical kind of a thing
because of the rapid heart rate; and a marked lowering of the blood pressure.
In terms of the nondihydropyridines, you get decreased proteinuria,
you can have decreased ischemia, and you can have bradycardia and AV blocks,
and sinus node depression when you're using these medications.
The other category of anti-anginals can be considered the beta-blockers.
Now, beta-blockers are often used in angina management,
they're often used in post M.I. management too.
The prototypical and oldest of the beta-blockers is propranolol,
although, ironically we don't really use proplanolol anymore for the treatment of angina.
Beta-blockers in general reduce heart rate.
They reduce cardiac force and they reduce blood pressure.
Beta-blockers are most effective at preventing angina. But they may also be used intravenously
for severe acute angina in the absence of contraindications.
It is not useful against certain types of vasospastic angina,
so you have to be careful when you're picking which patients you're going to treat with them.