Lectures

Carcinoid Syndrome

by Carlo Raj, MD
(1)

Questions about the lecture
My Notes
  • Required.
Save Cancel
    Learning Material 2
    • PDF
      Slides SmallAndLargeIntestineDiseases GastrointestinalPathology.pdf
    • PDF
      Download Lecture Overview
    Report mistake
    Transcript
    Our topic brings us to Carcinoid Syndrome. Here, once again, I wanna make sure that I clarify any doubt that you might have about carcinoid tumor syndrome or bronchiocarcinoid. Let?s begin. Tumors arising from entero-chromaffin like cell. Stop there. Entero-chromaffin. That?s sounds rather endocrine in nature and that?s exactly right. Therefore, anytime you find anything with carcinoid, please understand that you?re going to produce all these interesting peptides and I say interesting because there are approximately 40 of them. Of all the 40 or so, you?ll be paying attention to serotonin. The syndrome of watery diarrhea, flushing, bronchospasm, right heart failure, that?s a syndrome of versus tumor. So what happened? And that grows, aren't you seeing the same thing? No. Carcinoid tumor will be located in the intestine. It does not metastasize. My golly though, it is going to produce all these various peptides including serotonin. So you really, you don?t have any clinical manifestation of carcinoid tumor because these chemicals enter the portal vein, enter the liver, because the liver is not damaged and there?s no metastasis, the liver can handle everything that?s coming from the intestine. So there is no flushing, no right-sided valvular heart disease and definitely no bronchospasms. Carcinoid syndrome quite different. So what happens in carcinoid syndrome? It?s a fact that you have an entero-chromaffin tumor that has now metastasized from the intestine has now colonized the liver, behaves exactly like a carcinoid tumor but now you?re in the liver. Now you have to call this syndrome, all these chemicals, peptides will exit the liver because the liver will not have a chance to neutralize and detoxify and maybe a few but not much. Will enter the hepatic vein inferior vena cava. Where are you gonna enter? Right side. So you are going up right-sided....

    About the Lecture

    The lecture Carcinoid Syndrome by Carlo Raj, MD is from the course Small and Large Intestine Diseases.


    Included Quiz Questions

    1. Enterochromaffin cells
    2. PP cells
    3. Schwann cells
    4. Beta cells of islets of pancreas
    5. Ganglion cells
    1. 5-HIAA
    2. Insulin
    3. Glucagon
    4. Epinephrine
    5. Inhibin
    1. Tryptophan
    2. Tyrosine
    3. Threonine
    4. Methionine
    5. Lysine
    1. Carcinoid syndrome is only seen in the gastrointestinal tract.
    2. The active metabolites produced by carcinoid tumor is detoxified in the liver preventing the manifestation of symptoms.
    3. Carcinoid syndrome can produce flushing and watery diarrhea.
    4. Urinary levels of 5-HIAA is high in carcinoid syndrome.
    5. Symptoms suggests to metastasis to the liver from carcinoid tumor.

    Author of lecture Carcinoid Syndrome

     Carlo Raj, MD

    Carlo Raj, MD


    Customer reviews

    (1)
    5,0 of 5 stars
    5 Stars
    5
    4 Stars
    0
    3 Stars
    0
    2 Stars
    0
    1  Star
    0