Then, let's look at the other
end of the spectrum
with the California encephalitis virus.
This is transmitted specifically through
the bite of the Culex mosquito,
which is a forest-loving mosquito.
It's a larger mosquito,
and it bites especially at the
evenings and the mornings.
Fortunately, this is only a low
unpleasant to be sure, but spontaneous
recovery is nearly uniform.
In patients bitten by the infected
they have an incubation period of maybe
3-7 days, on average 4-5 days.
And it's right at the end of that incubation
period that one could start to detect
the RNA by an RT, reverse transcriptase, PCR,
especially if one obtains that specimen,
not necessarily just lung tissue but sputum,
and in the also serum, blood.
Clinical manifestations, that prodrome
with the flu-like illness,
fever, rigors, nausea, vomiting, headache.
The headache and lethargy is perhaps
in the California encephalitis virus
prodrome than it is with the hanta virus
that we just talked about.
And overall, the prodrome lasts
less long than it does with hantavirus,
so just 1-4 days.
Then, the patient develops
alteration of their level of consciousness,
in fact, becoming very confused.
Patients, especially children,
will develop seizures
and also focal neurologic findings,
which may be cranial nerve palsies,
and then ultimately, progressing into
coma for about 10% of patients.
Fortunately, again, the recovery
nd most all patients recover without
any significant neurologic sequelae.
So, 2 different viruses that we've
talked about in this family,
2 completely different clinical
and even with hantavirus, 2 different
So, a key takeaway from this
particular session is that
viral disease is going to appear
differently depending on its tropism,
depending on its intended target,
and what type of disease or what type
of cell tissue is destroyed by the virus.
Here ends the lesson.