California Encephalitis Virus – Bunyaviruses

by Sean Elliott, MD

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    00:01 Then, let's look at the other end of the spectrum with the California encephalitis virus.

    00:07 This is transmitted specifically through the bite of the Culex mosquito, which is a forest-loving mosquito. It's a larger mosquito, and it bites especially at the evenings and the mornings.

    00:21 Fortunately, this is only a low mortality infection, unpleasant to be sure, but spontaneous recovery is nearly uniform.

    00:31 In patients bitten by the infected Culex mosquito, they have an incubation period of maybe 3-7 days, on average 4-5 days.

    00:41 And it's right at the end of that incubation period that one could start to detect the RNA by an RT, reverse transcriptase, PCR, especially if one obtains that specimen, not necessarily just lung tissue but sputum, and in the also serum, blood.

    00:59 Clinical manifestations, that prodrome with the flu-like illness, fever, rigors, nausea, vomiting, headache.

    01:05 The headache and lethargy is perhaps more pronounced in the California encephalitis virus prodrome than it is with the hanta virus that we just talked about.

    01:16 And overall, the prodrome lasts less long than it does with hantavirus, so just 1-4 days.

    01:24 Then, the patient develops progressive drowsiness, alteration of their level of consciousness, in fact, becoming very confused.

    01:32 Patients, especially children, will develop seizures and also focal neurologic findings, which may be cranial nerve palsies, and then ultimately, progressing into coma for about 10% of patients.

    01:44 Fortunately, again, the recovery is spontaneous, nd most all patients recover without any significant neurologic sequelae.

    01:53 So, 2 different viruses that we've talked about in this family, 2 completely different clinical manifestations, and even with hantavirus, 2 different clinical syndromes.

    02:04 So, a key takeaway from this particular session is that viral disease is going to appear differently depending on its tropism, depending on its intended target, and what type of disease or what type of cell tissue is destroyed by the virus.

    02:20 Here ends the lesson.

    About the Lecture

    The lecture California Encephalitis Virus – Bunyaviruses by Sean Elliott, MD is from the course Viruses.

    Included Quiz Questions

    1. Culex
    2. Aedes
    3. Anopheles
    4. Ochlerotatus
    5. Culiseta

    Author of lecture California Encephalitis Virus – Bunyaviruses

     Sean Elliott, MD

    Sean Elliott, MD

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