Another type of non-Hodgkin’s
lymphoma brings us to Burkitt.
The Burkitt lymphoma, here, you
have endemic or non-endemic type.
The endemic type would be of the African,
non-endemic type is then
called the sporadic.
And associated with latent
EBV more so with endemic.
Here, the translocation will be 8;14
and the gene here will be C-myc.
The 14 again to you should mean
immunoglobulin heavy chain.
These translocations lead
to upregulation to C-myc
in which there’s going to be increased
promotion of growth and division.
Now, with Burkitt lymphoma,
the endemic type,
this African boy that you
probably have seen the picture of
and I’ll show you further,
is almost always
involving the mandible.
And if it’s a sporadic type,
you’re thinking about either the
abdominal or the pelvic region.
That will be the non-endemic type.
Histologic picture, once again, remember
this is a non-Hodgkin’s lymphoma
affecting the lymph node
and of B-cell origin.
Diffuse infiltrate of
You might have heard of the
term starry sky appearance.
A large number of mitotic
and apoptotic cells
and scattered benign macrophages
that you’re seeing here
then represents or create a picture
of what’s called starry sky.
By that we mean, that if you take a
look at the overall picture here,
appears as being dark blue.
In the middle, do you see
the twinkling stars?
That would be your
Clinically, Burkitt lymphoma, all
forms occur at extranodal sites.
Remember, non-Hodgkin’s lymphoma can
commonly be involved with extranodal.
The different types and their demographics,
please observe the jaw
and the mandible in this
child who’s suffering
from Burkitt lymphoma.
Non-endemic, known as sporadic.
Pelvic abdominal region
and you can have non-Hodgkin’s
lymphoma with HIV association.
Here, very aggressive.
Remember with HIV status, it is important
that you pay attention to your
non-Hodgkin’s lymphoma including
your diffuse large B-cell lymphoma.
Endemic and sporadic type, most common,
frequently seen in
children and young adults.
HIV can occur at any
age as you can imagine
and generally very aggressive,
responds well with short-term
and high-dose chemotherapy