Lymphadenopathy: Burkitt Lymphoma – White Blood Cell Pathology

by Carlo Raj, MD

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    Another type of non-Hodgkin’s lymphoma brings us to Burkitt. The Burkitt lymphoma, here, you have endemic or non-endemic type. The endemic type would be of the African, non-endemic type is then called the sporadic. And associated with latent EBV more so with endemic. Here, the translocation will be 8;14 and the gene here will be C-myc. The 14 again to you should mean immunoglobulin heavy chain. These translocations lead to upregulation to C-myc in which there’s going to be increased promotion of growth and division. Now, with Burkitt lymphoma, the endemic type, this African boy that you probably have seen the picture of and I’ll show you further, is almost always involving the mandible. And if it’s a sporadic type, you’re thinking about either the abdominal or the pelvic region. That will be the non-endemic type. Histologic picture, once again, remember this is a non-Hodgkin’s lymphoma affecting the lymph node and of B-cell origin. Diffuse infiltrate of medium-sized cells. You might have heard of the term starry sky appearance. A large number of mitotic and apoptotic cells and scattered benign macrophages that you’re seeing here then represents or create a picture of what’s called starry sky. By that we mean, that if you take a look at the overall picture here, appears as being dark blue. In the middle, do you see the twinkling stars? Yeah. That would be your scattered macrophages. Clinically, Burkitt lymphoma, all forms occur at extranodal sites. Remember, non-Hodgkin’s lymphoma can commonly be involved with extranodal. The different types and their demographics, endemic African, please observe the jaw and the mandible in this child who’s suffering from Burkitt lymphoma. Endemic. Non-endemic, known as sporadic. Pelvic abdominal region and you can have non-Hodgkin’s lymphoma with HIV association. Here, very aggressive. Remember with HIV status, it is important...

    About the Lecture

    The lecture Lymphadenopathy: Burkitt Lymphoma – White Blood Cell Pathology by Carlo Raj, MD is from the course Lymphadenopathy – White Blood Cell Pathology (WBC).

    Included Quiz Questions

    1. Epstein-Barr virus
    2. Echovirus
    3. Ebola virus
    4. Aichi virus
    5. Coxsackievirus
    1. c-Myc gene
    2. XPD gene
    3. BRCA1 gene
    4. HFE gene
    5. ABL1 gene
    1. Starry sky
    2. Pappenheimer bodies
    3. Reed-Sternberg cells
    4. Cartwheel appearance
    5. Rosette pattern

    Author of lecture Lymphadenopathy: Burkitt Lymphoma – White Blood Cell Pathology

     Carlo Raj, MD

    Carlo Raj, MD

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