Another type of non-Hodgkin's lymphoma brings us to Burkitt.
The Burkitt lymphoma, here, you have endemic or non-endemic type.
The endemic type would be of the African, non-endemic type is then called the sporadic.
And associated with latent EBV more so with endemic.
Here, the translocation will be 8;14 and the gene here will be C-myc.
The 14 again to you should mean immunoglobulin heavy chain.
These translocations lead to upregulation to C-myc
in which there's going to be increased promotion of growth and division.
Now, with Burkitt lymphoma, the endemic type,
this African boy that you probably have seen the picture of
and I'll show you further, is almost always involving the mandible.
And if it's a sporadic type, you're thinking about either the abdominal or the pelvic region.
That will be the non-endemic type.
Histologic picture, once again, remember this is a non-Hodgkin's lymphoma
affecting the lymph node and of B-cell origin.
Diffuse infiltrate of medium-sized cells.
You might have heard of the term starry sky appearance.
A large number of mitotic and apoptotic cells and scattered benign macrophages
that you're seeing here then represents or create a picture of what's called starry sky.
By that we mean, that if you take a look at the overall picture here,
in the middle, do you see the twinkling stars? Yeah.
That would be your scattered macrophages.
Clinically, Burkitt lymphoma, all forms occur at extranodal sites.
Remember, non-Hodgkin's lymphoma can commonly be involved with extranodal.
The different types and their demographics, endemic African,
please observe the jaw and the mandible in this child who's suffering from Burkitt lymphoma.
Endemic. Non-endemic, known as sporadic.
Pelvic abdominal region and you can have non-Hodgkin's lymphoma with HIV association.
Here, very aggressive.
Remember with HIV status, it is important that you pay attention
to your non-Hodgkin's lymphoma including your diffuse large B-cell lymphoma.
Endemic and sporadic type, most common, frequently seen in children and young adults.
HIV can occur at any age as you can imagine and generally very aggressive,
responds well with short-term and high-dose chemotherapy with management.