The bunyaviridae are mid-sized,
enveloped viruses which
have a helical capsid.
They also have a linear single-stranded,
negative-sense segmented RNA genome,
and so they must carry an RNA-
dependent RNA polymerase.
And you could see images
of the bunyaviridae
on the scanning electron micrograph
in front of you.
The representative species that we'll talk
about are the encephalitis viruses,
especially the California
And then hemorrhagic fever
viruses, including hantavirus,
and similarly, the sandfly/rift
valley fever virus,
and the Crimean-Congo hemorrhagic
Because these all manifest in
a similar fashion,
today we will just discuss, of
those, the hantavirus.
So, the bunyaviridae
primarily are arboviruses,
meaning that they are transmitted
through the bite of a biting insect,
but sometimes, fleas, flies, or ticks.
The exception, of course, is the hantavirus
that is transmitted by rodents,
including this cute little one in
front of you on the image.
The pathogenesis of the bunyaviridae
starts with primary infection,
regardless of whether it is via
the bite of a biting insect,
or via the stool or urine of
a infecting rodent.
After primary infection occurs
with the inoculation,
then flu-like symptoms develop, and
again, this is a very typical pattern
with many of the viruses we talk about.
The primary processes: fever,
some vomiting, diarrhea, general
sense of poor being.
And then there is a secondary viremia
after that primary infection,
and while the symptoms are ongoing,
and target organs are affected
depending on the virus and depending
on the virus' tropism.
And some of the target organs
are displayed here,
but especially the central nervous system,
especially for the encephalitis viruses,
liver, lungs, endothelium with
especially with the hantavirus.