00:01
Hello, welcome to the lecture on
bronchopulmonary dysplasia.
00:04
This is one of the
top respiratory problems
that premature infants live with.
00:09
Thanks to advances in
technology today.
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There's more premature infants
being born every day and surviving.
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They live with this condition
the rest of their lives.
00:18
We're gonna start by going over
what bronchopulmonary
dysplasia actually means,
and then the major causes of it,
as well as the manifestations,
prevention measures, and
treatment of the signs and symptoms.
00:32
Let's start
by going over the definition.
00:35
All right, let's start with a quick
review of terms.
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The word bronchopulmonary
means related to the bronchus,
or the bronchi, and the lungs.
00:46
Dysplasia means abnormal
cell growth or damage cells.
00:50
When there's abnormal cell
growth or damage cells in the lung,
such as the ones in the
right lower picture
with the damage or unhealthy
alveoli.
01:00
There's impaired gas exchange
and oxygen can't make it to the body
as well as it should.
01:08
Bronchopulmonary Dysplasia
basically means abnormal cell growth
or damaged tissue in the lungs.
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Infants are not born with this.
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It actually results from
damage that occurs after birth,
as a result of things that are
meant to help the patient breathe.
01:27
In immature lungs, when there's
damage to the lung tissue,
the inflammation can cause a cycle
of chronic abnormal cell growth
and repeated inflammation
after that cell growth.
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Both of these things result
in a more impaired gas exchange.
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Premature infants who require
oxygen therapy for more than 28 days
are considered to have BPD.
01:48
The more premature the newborn,
the more immature the lungs,
and the greater the risk
of developing BPD
because they're more at risk
for needing things
like mechanical ventilation
that can cause it.
01:59
It's actually a clinical diagnosis.
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There's no diagnostic test for it.
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The symptoms of respiratory
distress, radiographic findings,
and the time and length of their
need for oxygen or other support
all help determine
the diagnosis of BPD.
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According to the 2019 National Institute of Child Health andHuman Developmentâs
revised definition of BPD, If a preterm infant needs Nasal cannula flow of <2 L/min at 36 weeks gestational age,
they are considered to have mild BPD.
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Preterm infants who have moderate BPD
require Nasal cannula flow of >2 L/min or non-invasive positive pressure ventilation
such as nasal CPAP at 36 weeks PMA.
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Severe, is a need for Invasive PPV at 36 weeks PMA.
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Invasive PPV refers to PPV through an endotracheal tube or a tracheostomy tube.
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Okay, let's dive a little deeper
into how BPD occurs.
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BPD is actually considered a
complication of prematurity.
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Because it's something that
premature infants deal with,
it's not something
they're born with.
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It's most common and very small,
premature infants
who require some sortof assistance
with their breathing.
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The reason is,
assistance typically means
they need pressure
to deliver that assistance.
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And pressure can be damaging to
fragile immature lung tissue.
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Mechanical ventilation
and oxygen therapy
are both treatments
that while they help the patient,
they can also cause
damage to very fragile
or immature lung tissue.
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Remember that infants
are not born with BPD.
03:48
They develop it after birth
as a result of treatments
that they require.
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All right, let's take a look
at the premature lung.
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This picture at the top
is overstretched alveoli.
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This is what happens
when alveoli are subject
to a little too much pressure
in an effort to inflate them
and help with gas exchange.
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The bronchioles
lead to the alveoli,
which are the
little balloon light sacs
where gas exchange occur.
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When there's high amounts
of oxygen and pressure
that are pushed into them,
it can cause the alveoli
to become overstretched
or even to collapse.
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It can also cause the bronchioles
which are the little branches
that lead to the alveoli,
to get irritated and inflamed.
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When the alveoli become
overstretched or collapse,
they don't work as well.
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The same thing happens
when the bronchioles
become irritated and inflamed
as a result of both or either
gas exchange can occur
as well as it should.
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These effects are especially
damaging to premature lungs
that are still developing,
which is why
the more premature the infant
is at birth,
that usually the more severe
the damage is to their lungs
as a result of the treatments
meant to help them.
04:59
Infants before their lungs are
fully developed to require
administration of a special liquid
called surfactant,
which actually normally occurs
in normal full term lungs.
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It's something that's
usually present naturally,
but if it's not present,
the lungs can't function properly.
05:17
The surfactant deficiency is
actually the major cause of RDS
or Respiratory Distress Syndrome
in preterm neonates.
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Is closely linked to BPD,
but not all infants with RDS
will develop BPD.
05:30
All right, let's review
some specific examples of
some of the causes of BPD.
05:35
Sometimes BPD can happen
if another problem
that affects the lungs
in some way occurs,
such as, certain birth defects,
certain heart problems, or defects,
pneumonia, or some prenatal
or postnatal infections.
05:50
All these things can cause stress,
a lot of extra work
and sometimes damage or
injury to the lungs
which can contribute to BPD,
especially in a preterm
or premature infant.
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All right, now let's review how an
infant with BPD may present.
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Some of the signs and symptoms
that may occur in an infant with BPD
are similar to the signs and
symptoms of any infant
and respiratory distress.
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They may be very similar to other
forms of respiratory distress.
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They can include hypoxia,
or an inability to wean from oxygen,
breathing problems that may range
from increased work of breathing
through retractions,
like the sucking in of the skin,
under the sternum,
in between the ribs,
above the clavicles.
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They may have nasal flaring,
which is another sign of
air hunger and labored breathing.
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They may have wheezing,
abnormal breath sounds.
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You may not hear
good breath sounds at all.
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So, it really run the gamut.
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But you should be able to tell,
if you uncover the child
when you assess them,
when you have actually
put your stethoscope on them,
you should be able to tell
they're in respiratory distress.
06:59
They may also have
difficulty feeding,
and that is largely because
they can't breathe,
especially when they're feeding.
07:06
Repeated lung infections
may require hospitalization,
because these infants
typically are very vulnerable
to other infections and
other insults to their lungs.
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All right, now that we
know BPD has no cure.
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Let's talk about what we
can do to help prevent it
and into the respiratory distress
and immature lungs.
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Pretend like this is a
premature infant who's hypoxic,
who's requiring oxygen and
his respiratory distress,
and is suspected to have
BPD.
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What might be done?
So, surfactant given in the
first two hours of birth.
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If the child doesn't
have it already in their lungs,
coats the alveoli and helps them
work correctly.
07:45
It can also help prevent
them from collapsing.
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Another way to help prevent BPD,
is to use the lowest level
of pressure and oxygen
required to support them.
07:57
Using high frequency oscillatory
ventilation for intubated infants
also helps prevent BPD.
08:03
Because the gentler method of
delivering these ventilations.
08:07
And lastly, Vitamin A,
may actually be helpful,
because Vitamin A contributes to
airway cell growth and development.
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All right, now let's wrap up by
discussing some ways
to treat BPD once it develops.
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Sometimes the symptoms or
effects of it can be reduced.
08:25
But remember,
no cure exists for BPD.
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Preventing progression
of the condition is key.
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First, corticosteroids may be used
to help reduce inflammation,
However, side effects
have to be considered.
08:40
Hydration is always an issue and
needs to be monitored closely.
08:44
Infants who are in
respiratory distress
can sometimes even
become dehydrated
just because of
respiratory distress alone.
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Because the amount of
water vapor that is lost
through respiratory distress.
08:56
Antibiotics may be given
if they have a bacterial infection.
08:59
Because the infant with BPD
has a much higher risk of pneumonia
due to the fact they have
immature lungs at baseline.
09:06
And for the same reasons,
these infants should avoid
sick contacts
and receive all the recommended
childhood vaccinations.
09:16
The NCSBN develops the NCLEX exam.
09:20
This model is called the
Clinical Judgment Measurement Model.
09:23
The framework
and the terms within it
are being used in
the next generation
NCLEX test questions
and case studies.
09:30
So let me show you how to make some
connections between this model
and the content we just covered.
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We're going to emphasize
the first two important steps
of how to recognize cues, and
analyze cues in kids with BPD.
09:44
To recognize cues and an infant
who was Risk for BPD,
you must know
how to properly assess them,
their gestational age
and their work of breathing.
09:53
Signs and symptoms of
respiratory distress
are about the same no matter
the condition that is causing it.
09:58
Increased work of breathing
can include
retractions, or
sucking in of the skin,
anywhere from the substernal area
to the supraclavicular area,
to nasal flaring to abnormal
breath sounds or no breath sounds
or reduce breath sounds,
tachypnea, cyanosis,
other color changes in hypoxia.
10:17
At any time,
the infant's body is stressed.
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You can also expect
their heart rate to go up.