00:01
So how do patients present with bronchiectasis,
well the common types of presentation include
the following - One, it is a daily production
of purulent phlegm. So that could be a small
amount, a teaspoon of green gunky phlegm per
day or it could be as much as a cup or even
more per day with more severe disease. Now
that's a marker of patients who really do
have active bronchiectasis with quite significant
anatomical damage. The less marked disease,
the less severe disease patients may not have
daily purulent sputum production but will
have acute attacks of exacerbations whether
they produce green phlegm for a few days that
respond to antibiotics and makes them feel
better, but these keep coming back. Most patients,
most people do not get too many chest infections
in their life, if you're getting chest infections
every year or several times a year, that should
raise the suspicion that the patient
has a bronchiectasis unless they have an underlying
other lung disease such as COPD, or are they
known to smoke. Similarly sputum's cultures
are not normally positive in normal people
repeatedly, so if you keep identifying bacterial
organisms which are known to be pathogens
such as Haemophilus Influenzae, Morexalla,
Streptococcus pneumoniae or Staphylococcus
aureus from sputum samples in an individual
then you need to think that they might have
bronchiectasis and Pseudomonas aeruginosa
is a bacteria which only normally colonizes
abnormal lungs, so if you isolate that in sputum,
you really need to think about bronchiectasis
diagnosis. Aspergillus is found in the
lungs of patients with allergic bronchopulmonary
aspergillosis, and again if you culture it,
therefore you need to think about bronchiectasis
and ABPA as a diagnosis. Bronchiectasis is
one of the major causes of hamemoptysis, so
an episode of major hemoptysis or repeated
episodes of minor hemoptysis might suggest
bronchiectasis. The signs of bronchiectasis
are coarse crackles and somebody always has
coarse crackles in the same area of the lung
whenever you listen to them, then again that
would suggest that there's some damage there
and bronchiectasis is one of the possible
causes. And finally, with a CT scans
being used frequently
nowadays for accessing patients with lung disease
of various different types, then bronchiectasis
is often identified. For example in my clinic
I frequently see patients with being referred
from the two week wait clinic where patients
have been referred from investigation for
an abnormal X ray because people are worried
they may have cancer, but it turns out the
abnormality on the X ray is due to bronchiectasis.
Right, so common associations of bronchiectasis,
what other problems do patients of bronchiectasis
have? Well, they often have asthma, some reversible
airways obstruction, that’s the patients
with the mild forms of bronchiectasis.
02:45
The more severe forms of bronchiectasis, as I’ve
already mentioned leads to irreversible airways
obstructions, you get small airways obliterative
bronchiolitis and that is the mechanism by
which bronchiectasis causes patients to develop
respiratory failure and causes death.
03:01
Patients with bronchiectasis, specifically the
idiopathic patients and those with mucociliary
clearance problems such as cystic fibrosis,
they frequently have rhinitis, sinusitis,
middle ear disease, so upper airway problems as
well. Occasionally patients with bronchiectasis
will have infertility, that’s an example
of mucociliary clearance problems, affecting
sperm production as well, and infections with
non-tuberculosis mycobacteria are problems
as well. How do you recognize clinically on
examination patients? Combination of clubbing
and coarse crackles within the lung. Actually
clubbing is pretty rare unless the patient
has severe or aggressive disease. The crackles
though, are usually present in patients with
bronchiectasis, and they can be accompanied
by the squeaks and by wheeze of the airways
obstruction, and when the patients have really
bad bronchiectasis they will develop the signs
of severe airways obstruction as well, the
similar signs that we described in COPD.