Clinical Biochemistry

by Kevin Ahern, PhD

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    The process of proline hydroxylation, as I noted earlier, requires vitamin C. Without vitamin C, some really nasty things happen. A deficiency of vitamin C leads to the condition known as scurvy. Now, scurvy is a pretty serious disease. You can see in the picture on the lower right some drawings of a person who has scurvy. These are from ancient times. The disease has actually been known since at least the 13th century. Crusaders that went off on long crusades in the 13th century went and took with them primarily meat, salted meat because they didn’t have a way of preserving things. They didn’t have fruits and so forth and they didn’t know of the importance of those fruits. But as a result of going off and eating this solid salt meat diet, they developed a condition known as scurvy because they got no vitamin C in their diet. They went away as big hulking brutes and they came back literally falling apart. So, the value of citrus fruits for preventing scurvy has been known for as long as 1497 when the explorer, Vasco de Gama took off on a voyage. He took with him citrus fruits because there was this understanding that perhaps it might make a difference. Well, despite that knowledge and despite the fact that Vasco de Gama’s sailors came back and they had no scurvy unlike many other sailors at that time, over 2 million sailors died of scurvy between 1500 and 1800 which tells you a lot about how slowly information actually gets out. Now, proline hydroxylation is important as I noted earlier for increasing collagen’s thermal stability. Without it, it’s not stable at body temperature. But that also means that you can break it down by heating things up a fair amount. One...

    About the Lecture

    The lecture Clinical Biochemistry by Kevin Ahern, PhD is from the course RNA and the Genetic Code. It contains the following chapters:

    • Clinical Biochemistry
    • Interstrand Cross-Linking
    • Clinical Cases

    Included Quiz Questions

    1. It has been understood since about 1500.
    2. It arises from consumption of citrus fruits.
    3. It is increased with vitamin C.
    4. All of the answers are true.
    5. None of the answers are true.
    1. ...crosslinking is important for strengthening collagen.
    2. All of the answers are true.
    3. ...hydroxylation blocks lysine-lysine covalent bonds.
    4. ...crosslinking arises from lysine reduction.
    5. None of the answers are true.
    1. All of the answers are true.
    2. None of the answers are true.
    3. It ultimately requires vitamin C for function.
    4. It catalyzes a reaction necessary for secretion from the cell.
    5. It causes hydroxylation of lysine to hydroxylysine.
    1. Aldehydes of allysine can react with amines of other lysines to form pyridinoline.
    2. It occurs largely in the cytoplasm.
    3. It typically involves three hydroxyprolines.
    4. All of the answers are true.
    5. None of the answers are true.

    Author of lecture Clinical Biochemistry

     Kevin Ahern, PhD

    Kevin Ahern, PhD

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