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Beta Blockers – Drugs in Hypertension

by Pravin Shukle, MD
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    Let's move on to the beta blockers. There are still drugs that are acting through the sympathetic system. These are beta receptor antagonists. Now, there's many many beta blockers. There's the non-selective or first generation, the second generation which tend to be more beta 1 selective. And then the third generation that are non-selective, but also have other types of activity. There's the novel third generation drugs. They don't call them fourth generation simply because of legal reasons, but I often call them fourth generation. Now, these beta blockers, you can see that there's a huge list. You're not going to remember all of them. So, I'm going to cover a couple of them in more detail. These are the drugs that I think are worthwhile remembering. In the first generation class, remember propranolol. In the second generation class, remember metoprolol as it's prototypical agent and bisoprolol as the one that we use all the time. In the third generation class, carvedilol and labetalol are worth remembering. And in the novel third generation class, nebivolol which is a relatively new agent coming to the United States and Canada, but has been used extensively in Europe. Propranolol. As I said before, it is the prototypical beta blocker, not just of the first generation, but of all beta blockers. It is a short acting drug. And it has relatively poor blood pressure control. It is often used in anxiety control and in stage fright. And I always tell my patients and anyone who will listen that it can be used as a lie detector agent, so you can fool a lie detector test if you ever get interrogated by the CIA. Metoprolol is the prototypical cardiac beta blocker. It is usually a twice daily drug. There are once a day formulation as...

    About the Lecture

    The lecture Beta Blockers – Drugs in Hypertension by Pravin Shukle, MD is from the course Cardiovascular Pharmacology. It contains the following chapters:

    • β-Blockers
    • Notable β-Blockers
    • β-Blockers with Additional Activity

    Included Quiz Questions

    1. labetolol
    2. metoprolol.
    3. carvedilol.
    4. acebutolol.
    5. nebivolol.
    1. Carvedilol has alpha adrenergic blockade activity.
    2. Nebivolol has alpha adrenergic blockade activity.
    3. Metoprolol has beta 2 receptor blocking activity.
    4. Acebutolol has angiotensin converting enzyme blocking activity.
    1. Nebivolol has nitric oxide activity, causing direct vasodilation.
    2. Metoprolol will act on the alpha receptor also.
    3. Bisoprolol will act through the kallilikrein pathway.
    4. Labetolol has nitric oxide activity, causing direct vasodilation

    Author of lecture Beta Blockers – Drugs in Hypertension

     Pravin Shukle, MD

    Pravin Shukle, MD


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