00:00 Now I want to introduce you to this word paradoxical effect. 00:04 It's kinda fun. You have it. 00:05 This is an important word cuz we're gonna use it a lot in the next incoming part and I wanted to make sure you understood what it meant. 00:12 See, this is an effect of a medical treatment, usually a drug. 00:16 When we say a paradoxical effect, it's the opposite that's why we bolded that word for you. 00:22 So a paradoxical effect is the opposite to the effect which we normally would be expected. 00:28 So what the medication should do if it has a paradoxical effect that means it gives us the exact opposite effect. 00:36 So watch for this word as we talk through the rest of this video series. 00:40 Let's look at the impacts of benzodiazepine. On the CNS. 00:44 You might have possible paradoxical effects. So what would that be? Well, if I'm taking it to help me sleep, it may make my insomnia worse. 00:54 It may make me really excitable, it may make me euphoric or have increased anxiety or rage. 01:00 Not the goal when I take a benzodiazepine, right? When you look at those lists of the paradoxical effects, some people will respond this way. 01:10 So instead of improving their sleep, it makes it worse. 01:13 Instead of calming them down, it make them very excitable. 01:16 They might be just really euphoric. That's a problem cuz that's gonna be a risk for abuse. 01:21 They might have heightened anxiety so instead of feeling calmer, they feel more anxious or these huge mood swings of rage. 01:29 Nobody's taking a benzodiazepine with a goal of being rage-filled. 01:34 Now what about the cardiovascular system? Well, if you're taking an oral benzodiazepine, it's probably gonna have very little if any effect on the cardiovascular system. 01:45 IV benzodiazepines have a smaller chance of having hypotension but it's not a huge one. 01:51 But always be aware if you give an IV benzodiazepine to a patient, it may cause hypotension so keep an eye on their blood pressure. 01:59 Now the respiratory system is where it gets really, really dangerous. 02:03 The effects on the CNS are not great, minor effects on the heart, but the respiratory system is where this becomes life threatening. 02:12 Now if you take a benzodiazepine by itself, take an oral benzodiazepine, they have little to no respiratory depressive effect if that's the only thing you're taking. 02:22 So if you're prescribed a benzodiazepine, I wouldn't be really worked up about taking it. 02:27 I'm a little worried about the sleep stuff but other than that, you should be relatively okay, right? There shouldn't be a big problem as long as it resolves your symptoms. 02:36 That's if you take it alone, not with other medications, and especially not with alcohol. 02:42 And if it's a pill form, an oral form of benzodiazepine, it's gonna have little to no respiratory depressive effect. 02:49 Now, if you take a benzodiazepine with other CNS depressants like opioids, barbiturates, or alcohol, this is life threatening. 03:00 Now if you've watched the news, you've seen several celebrities who have taken multiple drugs at the same time. 03:06 Usually it's some type of combination of some of the drugs we just talked about there and that's what caused their untimely death. 03:14 So benzodiazepines plus any other drug or alcohol is gonna cause severe respiratory depression. 03:22 Don't do it. It's really, really dangerous. 03:26 Now it can also cause hypotension so keep an eye on that if you're doing -- if you're -- have a benzodiazepine with these other medications or alcohol not only suppresses the respiratory system, this is also an increased risk for low blood pressure. 03:41 Killer combo if you want to stay alive.
The lecture Benzodiazepines: Effects and Impact – Sedative Hypnotics (Nursing) by Rhonda Lawes, PhD, RN is from the course Central Nervous System (CNS) Medications (Nursing).
Which is a paradoxical effect of benzodiazepines on the central nervous system? Select all that apply.
Which statement is true of oral benzodiazepines? Select all that apply.
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