00:01
This is an overview
that you want to pay attention to
when you're dealing
with anemia.
00:06
Our doing here is the overview.
00:08
And what we will do later on
is then divide and dive into
each one of these categories
of different types of anemias.
00:16
Is that clear?
So for example,
under microcytic anemia,
which we will take on
at first.
00:21
First and foremost,
you pay attention to MCV being
less than 80.
00:25
And under microcytic anemia,
we will then walk through
the differentials
that you see here.
00:29
And these include
your iron deficiency,
anemia of chronic disease,
sideroblastic,
and also your thalassemia.
00:36
And I will tell you
how to approach this
when the time is right,
because really,
what you're doing here
is hemoglobin.
00:43
And so therefore, you divide
for pathologic purposes,
to make your life easier
with diseases.
00:48
You'll divide into
heme and globin.
00:50
Do that for me,
and you'll be in good shape.
00:52
And when we deal
with heme,
there are a lot of things
that we need to talk about there
with biochemistry.
00:56
Biochemistry,
is you should be thinking about
the porphyria pathway.
01:00
And if you're not familiar with it,
perhaps it would be
a good time for you
to take a look
at the porphyria pathway
with heme synthesis.
01:05
Whereas, your globin
would then be the genes.
01:08
You don't have control over genes,
that's something that you're given.
01:10
And we'll talk about the
alpha, beta, gamma, and delta,
and such.
01:14
Under macrocytic,
we'll divide this into
megaloblastic
and nonmegaloblastic.
01:21
And that becomes
really important for us.
01:23
So for example,
the megaloblastic here that are
often tested,
in folate deficiency
and vitamin B12 deficiency.
01:32
There are a couple others
that we have to address as well
under megaloblastic.
01:35
And those include Lesch-Nyhan syndrome.
01:37
And then you also have
Orotic aciduria.
01:39
Alright, so those are things
that are have shown up
are showing up,
and will show up.
01:44
Stick with me here,
and I will constantly feed you
current information constantly.
01:50
But what I'm saying is,
"Dr. Raj, I thought megaloblastic
was always macrocytic."
That is true.
Okay.
01:55
But the macrocytic don't always
doesn't have to be megaloblastic.
01:58
Really?
I thought they were
interchangeable.
02:00
No, they're not.
Please pay attention.
02:04
So you can have
macrocytic megaloblastic.
02:06
or you can have
macrocytic, nonmegaloblastic.
02:09
Is that clear?
So what's the difference?
The difference is the following:
What you're measuring here
with macrocytic
is going to be
for the most part,
the size of that RBC
in serum.
02:19
Is that clear?
That to you means
a circulation.
02:22
So therefore, if you're
thinking about
folate and vitamin B12
deficiency,
then don't you need that
for proper DNA synthesis?
Either pyrimidine or purine?
Sure.
02:32
So if you don't have
proper folate and B12 available,
how in the world can you
properly form normal RBCs?
You cannot.
02:41
Not only can you not
form proper RBCs,
you have, many, many,
many, many other issues,
including your WBCs
and such as well.
02:48
Would you please tell me
what an immature cell is called
in your bone marrow?
Oh, I see
what you're getting at.
02:57
That's a blast, isn't it?
There you go.
02:59
So whenever you have a blast
this to you should mean
that you have a problem
in the bone marrow.
03:04
Is that clear?
Whereas, if you take a look at
the category of nonmegaloblastic,
it's still macrocytic.
So what does that mean?
MCV greater than 100.
03:15
Now you can be more technical
in terms of dividing
megaloblastic and nonmegaloblastic
with 110 femtoliters,
but that's a bit much
right now.
03:22
But the under
nonmegaloblastic though,
this would mean that
from the bone marrow,
there was no problem.
03:27
Not B12.
Not folate deficiency.
03:29
Under nonmegaloblastic
you have things like
liver disease, alcohol use disorder,
and reticulocytosis.
03:36
Alright, so, there was a things
that I will mention,
but in terms of going in detail,
if I were you,
I'd be paying attention
to alcohol.
03:44
Alcohol does a lot of things.
03:45
"Dr. Raj, I thought alcohol
would then consume your folate."
Yes, it does.
So be smart, though.
03:51
So if your alcoholic
has megaloblastic anemia,
it most likely was due to?
There you go,
folate deficiency.
03:58
See what I'm getting at?
What else could alcohol do?
We'll talk.
04:03
Alcohol could also result
in a very common form
of acquired type
of a sideroblastic anemia.
04:08
And what's sideroblastic anemia?
Take a look.
04:11
Microcytic.
04:11
You see this, okay.
04:12
So these are things
that I'll be doing you're
setting up an overview.
04:15
I am spending
a little bit of time here
so that you keep these
arms and branches of your anemias
all well organized,
shall we say?
Okay, then what do we do?
Divide our normocytic.
04:27
So, normocytics are going to be
the largest of all of the anemias.
04:33
So, be careful, just because
you find an MCV,
take a look
between 80-100
all it does is put you
in the category of anemia.
04:43
Normocytic specifically.
04:45
And your patient is going to what?
Come with?
Fatigue and tiredness,
right?
That's all
he or she knows.
04:51
And then you will then take
the proper history,
and then you will
figure out
and the way
that you want to do this,
ladies and gentlemen,
all I'm doing here is setting up
the organization pattern
is divided into
nonhemolytic and hemolytic.
05:03
So I would like for you
to take a look at the category
in the far left here.
05:07
And those are all
nonhemolytics.
05:09
What does that mean?
For the most part,
as a rule of thumb,
for example,
let's say that you have
a patient has Parvovirus B19.
05:17
Reflex.
05:18
Your thinking aplastic anemia,
correct?
Maybe your patient is taking
chloramphenicol.
05:23
Maybe your patient is receiving
chemotherapy.
05:26
Maybe, maybe,
the kidneys got damaged.
05:29
What does all
all these have in common?
Kidneys got damaged,
no erythropoietin.
05:34
No erythropoiesis.
Oh, okay.
05:36
Next, chemotherapy.
05:37
Bone marrow shut down,
suppression,
oh...
05:40
no bone marrow function,
okay.
05:41
Parvovirus B19.
05:43
It hits the bone marrow,
what happens?
Aplastic.
05:46
Okay.
You see my point?
If you're never able
to properly form your RBCs
from the bone marrow,
how in the world can you possibly
destroy them?
You cannot.
05:57
So therefore,
these are nonhemolytic.
05:58
Are we clear?
Now, you tell me
where the grave site is for an RBC.
06:03
The grave site for an RBC...
06:05
Good. The spleen.
06:06
And so therefore,
all the two categories
that you see here,
the one in the middle,
and the one on the right.
06:11
For you,
those are all hemolytics.
06:14
And we walked through
all of these in detail.
06:17
So all of these
will at some point,
then end up
at the spleen,
or maybe even perhaps
intravascular.
06:22
But guaranteed,
there's going to be destruction
of that RBC
because there was no problem
with the bone marrow.
06:27
Hence, we call it
hemolytic anemia.
06:30
Before I move on,
there was one other concept
that I have to introduce now.
06:34
And then we'll go into
a greater detail
when the time is right.
06:37
And that is going to be
what's known as
what current a practice called?
Reticulocyte Production Index,
or RPI.
06:42
It's a concept
that you want to know.
06:44
And really, it comes down
to what's known as
corrected reticulocytes.
06:48
And luckily, now
there is calculations and such,
you can just plug it into
your computer, or app, or whatever.
06:54
And they will tell you
the proper RPI.
06:56
But before you go here though,
you must understand
what's happening.
06:59
Can I ask us something?
If the bone marrow,
which is the first column,
or first category,
normocytic here
has been shut down,
I'm not able to produce any RBCs,
alright.
07:11
So, if you're not able
to produce any RBCs,
we're able to produce
any type of reticulocytes.
07:19
What is a reticulocyte?
We'll go into detail
about reticulocyte.
07:22
It's the fact that
it's an immature RBC.
07:24
The point is this,
if you're bone marrow
has been shut down,
there is no way that you can produce
any reticulocyte.
07:30
So what do you expect your RPI or
corrected reticulocyte count to be?
Know the concept first,
decreased.
07:37
Good?
So here, you're thinking
less than 3%.
07:41
Whereas, the RBCs
are being destroyed
in mass by the spleen
or intravascular.
07:48
So now what happens?
Bone marrow has to
turn turn turn turn, alright?
You put it into overdrive.
07:54
Overdrive.
07:55
And what are you turning out?
The bone marrow is spitting out
reticulocytes.
08:01
Clear?
So therefore,
you'd expect there to be
an increase in reticulocytes.
08:08
We call this greater.
08:10
We mean,
actual value greater than 3%.
08:12
And that will be
for any hemolytic.
08:14
So now, well,
you ask more questions later on,
but understand the concept.
08:18
So here's a nice little
overview.
08:20
Not to worry.
08:21
Obviously,
we're going to repeat,
repeat, repeat, repeat
everything that I said.
08:25
But hopefully,
you have now developed
a proper organization pattern.