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Alzheimer's Disease (Senile Dementia)

by Carlo Raj, MD
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    Let’s talk about Alzheimer’s disease. The most common cause of dementia in elderly: slow, relentless, and it’s progressive. Oh man, you know when this kicks in, that poor patient. And actually, beyond that, what about the surrounding family and friends, huh? Really frustrating. Introduce yourself every single day and there’s no guarantee that he or she might remember you the next day. Initial symptoms of forgetfulness and memory disturbances. Initial. Progressive issues with language, and of course, loss of higher function referring to the memory, language skills and such. And the total duration from initial symptoms to death, well, it varies but in general, about a decade, and this is something that you want to keep in mind. At some point in time, we’ll get into more of your rapid onset, but a decade, in general, from initial onset until death. Varies from patient to patient. Risk factors: older age, female sex, head trauma, family history, genetics. And if you were doing imaging, and it’s a beautiful little schematic. Let me show you as to what we’re looking at here. On your left is a control or the normal. I want you to hone in on the hippocampus. And the hippocampus, of course, is responsible for storing your memories. And if you compare this control to our patient who has Alzheimer’s disease, well, would you please first take a look at the size of the brain compared to control and the disease on your right? You’ll notice that the size of the brain is extremely, well, much significantly smaller. That’s because of your cerebral cortical atrophy. In addition, what about the sulci? What does sulci mean? It’s the actual crevice, huh? It’s the crevice between the gyri, and you should know that with anything that is causing cerebral atrophy, that...

    About the Lecture

    The lecture Alzheimer's Disease (Senile Dementia) by Carlo Raj, MD is from the course Dementia. It contains the following chapters:

    • Alzheimer's Disease
    • Genetic Factors Linked to AD

    Included Quiz Questions

    1. Low IQ
    2. Old age
    3. Family history
    4. Female sex
    5. Previous head trauma
    1. Frontal atrophy
    2. Decrease size of the brain
    3. Increase in ventricle size of the brain
    4. Cerebral atrophy
    5. Hippocampus dilatation
    1. Rupture of bridging arteries
    2. Rupture of middle meningeal arteries
    3. Rupture of coronary sinus
    4. Rupture of Flax cerebri
    5. Rupture of middle meningeal vein
    1. Trisomy 21
    2. Trisomy 13
    3. Trisomy 18
    4. Defect in chromosome 15
    5. Defect in sex chromosomes
    1. Amyloid precursor protein
    2. Beta amyloid molecule
    3. Beta globulin
    4. Immunoglobulin
    5. Prp
    1. Trisomy 18
    2. APO e4 mutation
    3. APP mutation
    4. PS1 mutation
    5. PS2 mutation

    Author of lecture Alzheimer's Disease (Senile Dementia)

     Carlo Raj, MD

    Carlo Raj, MD


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